GHS Classification Result

Chemical Name:Antimonate(2-), bis[mu-[2,3-di(hydroxy-kappaO)butanedioato(4-)-kappaO1:kappaO4]]di-, dipotassium, trihydrate, stereoisomer
CAS:28300-74-5

Result:
ID: 1127
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG is classified into 6.1 and III according to the UNRTDG No. (1551). Since 4.1 was not assigned, it was considered as out of Category.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of UNRTDG No. 1551, Class: 6.1, III (not Class: 4.2)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG No. 1551 Class: 6.1, PG III (not Class: 4.2)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 1551, Class: 6.1; PG III (Not 5.1).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 3, because the LD50 in rats was 115mg/kg in RTECS (2004). [Note] Since there is little health hazard data for the anhydride of potassium antimonyl tartrate (CAS No.11071-15-1), we performed the investigation and classification by treating the substance as the trihydrate (CAS No.28300-74-5).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since it is supposed that there is skin irritation (HSFS (2004) and SITTIG (4th, 2002)) and there also the statement that the this product in ointments indicates mild irritation in early stages of use (a rash is produced in long-term uses) (HSDB (2005)), it was set as category 3.
3 Serious eye damage/eye irritation Classification not possible - - - - Although in HSFS (2004) and SITTIG (4th, 2002) there is eye irritation, the data which is supported is not found, and data is insufficient. Hence it cannot be classified.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The chromosome aberration inducement by the rat equivalent to somatic cell in vivo mutagenicity test (RTECS, 2004), and the chromosomal abnormality to the patient's lymphocyte medicated with this product were seen. So it was set as Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is classified into 2B as antimony compounds in industrial hygene academic society advice (2005). It was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a report in ACGIH-TLV (2005), a Priority 1 document, that in the form of an antimony compound it has airway irritant properties. The substance was classified as Category 1 (respiratory system) because there is also a report in SITTIG (4th, 2002), a Priority 2 document, of its airway irritant properties and pulmonary edema after exposure at a higher concentration.
9 Specific target organ toxicity - Repeated exposure Category 1 (lung, cardiovascular system), Category 2 (liver) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (lung, cardiovascular system)
H373: May cause damage to organs through prolonged or repeated exposure (liver)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since, in ACGIH-TLV (2005) of Priority 1 document, it is supposed that it has the effects on the lungs and the cardiovascular system by as an antimony compounds and there is description of the influence into the lungs and the heart of humans also (HSDB(2005), HSFS (2004) and SITTIG (4th, 2002) of Priority 2 document), it was classified into Category 1 (lungs, cardiovascular system). Moreover, in HSFS (2004) of and SITTIG (4th, 2002) Priority 2 document, there is the description of influence to human liver, so it was classified into Category 2 (liver). (The effects on the liver was observed also in the test of rabbit and rat, and the dose as which toxicity was observed was within the range of Category 2 in comparison with a guidance value (HSDB (2005) and RTECS (2004)).)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=12000microg/L of fishes (Fathead minnows) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3, since acute toxicity was Category 3, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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