GHS Classification Result

Chemical Name：Sodium nitrite
CAS：7632-00-0

Result：
ID: 1110
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified based on UNRTDG No. 1500, Class: 5.1(6.1), PGIII, though being nitrates containing N-O bonds as chemical groups associated with explosive properties present. The substance has a high reactivity and could explode by the contact of various substances, fire, or heat (ICSC(J), 200; Sax, 11th, 2004).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Nonflammable (ICSC (J), 2000). (However, this product is highly reactive and combustion is promoted by a contact with other substance. (ICSC(J), 2000))
8 Self-reactive substances and mixtures Not applicable - - - - Classified in oxidizing solids
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2000)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 3 Warning H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		UNRTDG No. 1500, Class: 5.1(6.1); PG III.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the statistical analysis of the rat LD50 values: 180mg/kg (RTECS, 2004), 85mg/kg (IUCLID, 2000) and 200mg/kg (IUCLID, 2000), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data. (It is a solid. But there is no vapor pressure information, and it is unknown whether exposure to vapor is possible.)
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 1 because of "SPECIES: Rat; ENDPOINT: LC50; VALUE: 0.0055mg/L/4H; VALUE: 5.5mg/m3/4H" (RTECS, 2004)
2 Skin corrosion/irritation Not classified - - - - There is possibility of skin irritation (HSFS (1999)). But it carried out the outside of category since skin irritation was not seen by the test (compliance with GLP) of the rabbit (IUCLID (1999)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since the result is Mild (RTECS(2004)) and Moderate (IUCLID (2000)) (correspond to GLP) in the eye stimulativeness examination in the rabbit, it was classified into Category 2A-2B. In addition, it is difficult to subdivide the Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - It is negative in the mice dominant lethal test (IUCLID, 2000), the multigeneration translocation study (IUCLID, 2000; HSDB, 2003), the marrow small core examination of rats and mouse, and the mouse peripheral blood small core examination (NTP TR495, 2001). So it carried out the outside of Category. This micronucleus negative findings is supported also in WHO (JECFA FOOD ADDITIVES SERIES: 50, NITRITE, 2003). In addition, although two or more negativity and a positive report were made by IUCLID (2000) in the chromosome aberration test / micronucleus test of rodent, detaileds are unknown and it was not used for the classification.
6 Carcinogenicity Not classified - - - - The descriptions that the results were negative for male and female in the carcinogenicity tests using rat, and the result was negative for male and indeterminacy for female in the carcinogenicity tests in mouse (NTP TR495 (2001)). But these findings are evaluated as negative by WHO. Therefore, it was out of the Category (JECFA FOOD ADDITIVES SERIES:50, NITRITE, 2003).
7 Reproductive toxicity Not classified - - - - In the study of the rat and mouse (JECFA (WHO FOOD ADDITIVES SERIES:50, NITRITE, 2003) and HSDB (2003)), since the impact on reproductive potential and teratogenicity were not admitted, they carried out the outside of Category.
8 Specific target organ toxicity - Single exposure Category 2 (cardiovascular system, blood) Warning H371: May cause damage to organs (cardiovascular system, blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2 (cardio-vascular system, blood) because there are reports that it affects the cardio-vascular system (decrease of blood pressure, etc.) and blood (methemoglobinemia, etc.) in ICSC (J) (2000), HSFS (1999), HSDB (2003), RTECS(2004), which are Priority 2 documents.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the repeat-administration studies to a rat, there were 2 reports of methemoglobinemia (RTECS (2004) of Priority 2 document), and it was classified into Category 2(blood) by comparison with the dosage for which toxicity was observed, and a guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.36mg/L of fishes (Rainbow trout) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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