GHS Classification Result

Chemical Name:N',N'-dimethylcarbamoyl(methylthio)methylenamine N-methylcarbamate
CAS:23135-22-0

Result:
ID: 1100
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data, though the substance contains N-O bonds as chemical groups with explosive properties present and has the oxygen balance calculated at -142.3, higher than -200 of the criteria.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains N-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - The test suitable for the solid with a melting point of 140 degC or less has not been established. (melting points: 100.8 degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (Melting point: 100.8degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
In two Acute Oral Toxicity tests in rats, we compared the LD50 values for male and female rats. Then for the lower of these groups we compared the LD50 values between the two tests, and selected the lower of the two. Based on the value LD50=5.4 mg/kg (Agricultural Chemical Registration Data), which was the lower value of the data from the two tests, the substance was classified as Category 2.
1 Acute toxicity (Dermal) Classification not possible - - - - There was a description of LD50 >1200mg/kg in the acute dermal toxicity tests using rats. But LD50 value was not obtained (Agricultural Chemical Registration Data), it was determined that it cannot be classified.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as category 2 based on the statement (Agricultural Chemical Registration Data) of LC50 = 0.064mg/L of the rats acute inhalation toxicity study.
2 Skin corrosion/irritation Not classified - - - - Based on the statement (Agricultural Chemical Registration Data) that irritation was not admitted by the skin irritation test using a guinea pigs, it carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - Based on the description that it has no irritation by the eye irritation tests using rabbit (Agricultural Chemical Registration Data), it is out of the Category .
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the statement (Agricultural Chemical Registration Data) with negativity by the skin sensitization study using a guinea pig, it carried out the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is no data of human administration cost epidemiology, an administration cost mutagenicity test, and a productive cell in vivo mutagenicity test. And there is the statement (Agricultural Chemical Registration Data) with negativity in the somatic cell in vivo mutagenicity test (micronucleus test which used mouse bone marrow cells). So it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - In the carcinogenicity tests using rat and mouse, based on the description that the treatment-related increased tumor was not observed (Agricultural Chemical Registration Data), it was out of the Category.
7 Reproductive toxicity Not classified - - - - In the rat reproduction study, the effects to fertility was not acknowledged and it was carried out the outside of Category based on the description that both rats and rabbits have no teratogenicity at teratogenicity studies (Agricultural Chemical Registration Data).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 1 (central nervous system). Based on the reports that symptoms indicating the effects on the central nervous system, such as clonic convulsions, salivation, lacrimation, ocular hemorrhage, spasms, becoming pale, protrusion of the eyeballs, facial spasms and dyspnea were observed in rats at the dosages within the guidance values for Category 1 in an acute oral toxicity test (2.5-20.0mg/kg )and an acute inhalation toxicity test (0.020-0.090mg/L) (Agricultural Chemical Registration Data).
9 Specific target organ toxicity - Repeated exposure Category 1 (systemic toxicity, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (systemic toxicity, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified into Category 1 (systemic, nervous system) based on the description that in 90-day oral toxicity study to rat with the dose (2.03-8.37 mg/kg) within the range of guidance value in Category 1, decreased weight gain, the abnormalities of haematologic and biochemical inspection items, change of organ weight, inhibition of a hemocyto and brain cholinesterase activity, tremors, and gait abnormality were observed (Agricultural Chemical Registration Data).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=0.319mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2005).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.47(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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