Chemical Name：2,3-dihydro-2,2-dimethyl-7-benzofuryl 2,4-dimethyl-6-oxa-5-oxo-3-thia-2,4-diazadecanoate
CAS：65907-30-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Among three LD50 value of oral administration examination for male and female rats (Agricultural Chemical Registration Data), the lower value of LD50=10 mg/kg was adopted to classify as category 2.
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It was set as Category 5 based on rat LD50 = 2020mg/kg of the dermal administration test (Agricultural Chemical Registration Data).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 based on LC50 = 0.24mg/L.: this is the lower value of LC50 = 0.24mg/L. and LC50 = 0.16mg/L (Agricultural Chemical Registration Data) by the inhalation exposure test using rats.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	It was referred to as Category 1 based on the publication (Agricultural Chemical Registration Data) that the positive result was obtained in the skin sensitivity test using a guinea pig.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no data of human administration cost epidemiology, an administration cost mutagenicity test, and a productive cell in vivo mutagenicity test. And there is the statement (Agricultural Chemical Registration Data) with negativity in the somatic cell in vivo mutagenicity test (micronucleus test which used mouse bone marrow cells). So it carried out the outside of Category.
6	Carcinogenicity	Not classified	-	-	-	-	In the carcinogenicity tests using rat and mouse, based on the description that there is no treatment-related tumorigenesis (Agricultural Chemical Registration Data), it was out of the Category .
7	Reproductive toxicity	Not classified	-	-	-	-	In the two-generation reproductive examination using rats and the teratogenicity study using rats and rabbits, it was carried out the outside of Category based on the description that reproductive toxicity was not acknowledged (Agricultural Chemical Registration Data).
8	Specific target organ toxicity - Single exposure	Category 1 (systemic toxicity, nervous system)		Danger	H370: Causes damage to organs (systemic toxicity, nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	There is a report that symptoms, such as decrease in locomotor activity, motor ataxia, tremors, bloody tears, contraction of the pupil, protrusion of the eyeballs, gasping, lacrimation, convulsions, excessive urination, dyspnea, salivation, swelling of the neck, marks of bite wounds on the tongue, nasal discharge and bleeding in the mouth, were observed at the dosages (5.9-186.0mg/kg) within the guidance values of Category 1 (Agricultural Chemical Registration Data). It is also reported that symptoms, such as locomotor activity, motor ataxia, tremors, lacrimation, convulsions, excessive urination and salivation, were observed at the dosages (8.0-253.0mg/kg) within the guidance values for Category 1 (Agricultural Chemical Registration Data). The substance was classified as Category 1 (systemic, nervous system) based on this information.
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood), Category 2 (nervous system)		Danger Warning	H372: Cause damage to organs through prolonged or repeated exposure (blood) H373: May cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified into Category 1 (blood) and Category 2 (nerve systems) based on the descriptionthat in a rat, with the dose (6.95-8.38 mg/kg) of guidance value within the range of guidance value in Category 1, inhibition of plasma, red blood cell and brain cholinesterase, and tendency toward anemia were observed, and in the dose (36.81 mg/kg) within the range of guidance value in Category 2, the decreased weight gains, consumption decreases, inhibtion of plasma, red blood cell and brain cholinesterase, and an tendency toward anemia were observed (pesticide registration application documents) .
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour LC50=1.8microg/L of Crustacea (Water fleas) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.7 (PHYSPROP Database, 2005)).