GHS Classification Result

Chemical Name：arsenic sulphides, natural
CAS：1303-33-9

Result：
ID: 1094
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (NFPA, 13th, 2003)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (NFPA, 13th, 2003)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (NFPA, 13th, 2003)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Literature has the description "it is insoluble to water", and it carried out the outside of Category. (Although NFPA (13th, 2002) has the description that "it reacts with waters and vapors, and flammable gases hydrogen sulfide is generated", the mark which indicates a water reactive substances to ibidem is not attached, but it is indicated that volumes of water should be used in the case of fire extinction.)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 185 mg/kg; REFERENCE SOURCE: RTECS (2004); HSDB (2003)
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 from rat dermal LD50 = 936mg/kg (RTECS, 2004;HSDB, 2003).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From the description that skin irritation is indicated as an arsenic compound of this product or of 3 values (HSDB, 2003;HSFS, 1998) and that description which shows that an inorganic arsenic had irritation (DFGOT 21, 2005), it was judged to have slight irritation, and it was set to category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Due to the descriptions that this product irritates to human eye (HSDB, 2003; HSFS, 1998), and that the arsenic compounds particulate irritates to the eye (DFGOT 21, 2005), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - It is not a deterministic conclusion (ATSDR, 2005; HSG, 1992) although there is no knowledge of the quality of a genuine article itself and skin sensitization may be shown to humans as an inorganic arsenic compound, in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient.
5 Germ cell mutagenicity Not classified - - - - Since it was negative in the mouse bone marrow micronucleus tests (EHC 224, 2001), it carried out the outside of Category.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004). So it was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although the knowledge of this product was not observed, it was considered as Category 2 based on the description related to human of EHC 224 (2001) which is Priority 1 document, about arsenic and arsenic compound, "the effect on reproduction is suggested ", and knowledge of animals "fetus toxicity and teratogenicity in dose in which maternal toxicity is observed". In addition, there is the description that "the conclusion which is inorganic arsenic is not teratogen in humans is advocated " in Catalog of teratogenic agents (2004) equivalent to Priority 1.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) Danger H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there was no information about this substance, the substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system) based on the report that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and based on a similar report in PIM (Poisons Information Monographs) G042 (WHO/IPCS, 1996). In addition, there is a report in ACGIH (7th, 2001) that it affects the liver, upper airways and lungs.
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Although the knowledge of this product was not observed, based on the description in the humans about arsenic and inorganic arsenics compounds, "gastrointestinal disturbances, neuropathy, affect to blood systems, and disorders of cardiovascular systems, kidney and liver were observed in the long term administration of inorganic arsenic. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow and peripheral nerves were also affected." (EHC 224 (2001), and PIM(Poisons Information Monographs) G042 (WHO/IPCS, 1996)) and the description of effect on the upper respiratory tract and lungs (ACGIH (7th, 2001)), therefore it was classified into Category 1 (digestive tract, cardiovascular systems, nervous systems, kidney, liver, blood systems, skin, respiratory system)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 4, since it is a metallic compound, and behavior in water is unknown, though no acute toxicity is reported within the saturated aqueous solution.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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