NITE - Chemical Management Field

GHS Classification Result

Chemical Name：arsenic trichloride
CAS：7784-34-1

Result：


ID:	1091
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	-	-	-	-	Non-combustible (ICSC(J), 2000).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	Not combustible (ICSC (J), 2000)
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (ICSC(J) (2000))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Although it reacts with water and hydrogen chloride gas occurs, the gas is noncombustible.
13	Oxidizing liquids	Classification not possible	-	-	-	-	No data available
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Although HSDB (2003) and ICSC (J) (2000) have the statement which indicates corrosion behavior, since there is no test data and data is insufficient, it cannot be classified.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	SPECIES: Rat; ENDPOINT: LD50; VALUE: 48 mg/kg; REFERENCE SOURCE: RTECS (2004)
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It is based on rat dermal LD50 = 80mg/kg (RTECS, 2004).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	From the description that this product stimulates (seriously) the human skin (ICSC, 2000;HSDB, 2003), it was set to category 2.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Due to the decstiption that this product irritates (seriously) to human eyes (ICSC, 2000;HSDB, 2003), it was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	It is not a deterministic conclusion (ATSDR, 2005; HSG, 1992) although there is no knowledge of the quality of a genuine article itself and skin sensitization may be shown to humans as an inorganic arsenic compound, in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 from the positivity (RTECS, 2004) in the mouse peripheral blood small core examination.
6	Carcinogenicity	Category 1A		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004). So it was classified into Category 1A.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as category 2 based on the description that "In animal experiments, a possible that inducing malformation to humans is suggested" in ICSC (2000) of Priority 2 document, and "reproductive effect is suggested " about arsenic and an arsenic compound about a human of EHC 224 (2001) in Priority 1 document. And knowledge in animal "fetus toxicity and teratogenicity at dose in which the maternal toxicity is observed". In addition, there is the description that "the conclusion which inorganic arsenic is not teratogen in humans is advocated " in Catalog of teratogenic agents (2004) equivalent to Priority 1.
8	Specific target organ toxicity - Single exposure	Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system)		Danger	H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system) based on the following reports that it affects the gastrointestinal system, cardio-vascular system and central nervous system and may cause serious gastroenteritis, bodily fluid and electrolyte losses, cardiac problems and convulsions, and cause severe irritation to the airways (ICSC, 2000), and that it affects the heart, liver, kidneys, pancreas and stomach, and causes irritation to the airways (HSDB, 2003), and that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)) and a similar report in PIM (Poisons Information Monographs) G042 (WHO/IPCS, 1996), and that it affects the liver, upper airways and lungs (ACGIH (7th, 2001)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the description that it affects mucosa, the skin, the peripheral nervous system, liver, and marrow, and pigment disorders, hyperkeratosis, nasal septal perforation, neuropathy, liver damage, and anemia may be occured (ICSC, 2000), the description in the humans about arsenic and inorganic arsenics compounds, "gastrointestinal disturbances, neuropathy, affect to blood systems, and disorders of cardiovascular systems, kidney, and liver were observed in the long term administration of inorganic arsenic. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow and peripheral nerves were also affected." (EHC 224 (2001), and PIM(Poisons Information Monographs) G042 (WHO/IPCS, 1996)) and the description of effect on the top respiratory tract and lungs (ACGIH (7th, 2001)), therefore it was classified into Category 1 (digestive tract, cardiovascular systems, nervous systems, kidney, liver, blood systems, skin, respiratory system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Insufficient data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	Classification not possible due to lack of data

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）