GHS Classification Result

Chemical Name：sodium dioxoarsenate
CAS：7784-46-5

Result：
ID: 1088
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in 2006)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (BGIA, GESTIS-database on hazardous substancess, accessed in 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (readily soluble)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 2027, Class: 6.1; PG II (Not 5.1).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 42mg/kg; REFERENCE SOURCE: EHC 224 (2001)
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on rat LD50 = 150mg/kg (RTECS, 2004).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description of "which indicates stimulant to the skin" on Chemical Safety Data Sheets Vol.4 a/The Royal Society of Chemistry (1991) equivalent to Priority 2. Moreover, SITTIG (47th, 2002) has description of "irritation may be indicated in the skin, an eye, and membrane."
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is the description that the similar descriptions in humans "(may) irritates to skin, eye, and membrane" (SITTIG (4th, 2002) of Priority 2 and Chemical Safety Data Sheets Vol.4 a/The Royal Society of Chemistry (1991) equivalent to Priority 2). So it was classified into Category 2. It is difficult to subdivide the Category 2A and 2B. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - From the description "development of the skin sensitization of inorganic arsenic is rare" in the humans of EHC 224 (2001) of Priority 1, and it was negative in maximization test of the guinea pig, it carried out the outside of Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is two or more knowledge which induces micronucleus/chromosome aberration in the in vivo mouse marrow from description of EHC 224 (2001), it is negative in the mouse dominant lethal tests. So it is set as 2.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since all existing classified materials in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004) are categorized into human carcinogens (as arsenic and arsenic cmpds), it was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2 from the description about the humans of EHC 224 (2001) of Priority 1 "effect on reproductive is suggested" and knowledge in animal "fetus toxicity and teratogenicity at the dosage in which maternal toxicity is observed " and the description in the humans of Catalog of teratogenic agents (2004) equivalent to Priority 1"the conclusion that inorganic arsenic is not teratogen in humans is supported."
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, cardiovascular system, nervous system, blood system, kidney), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, blood system, kidney)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, blood system and kidneys) and Category 3 (airway irritant). Based on the report that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and based on a similar report in PIM (Poisons Information Monographs) G042 (WHO/IPCS, 1996), and as well as the reports of "airway irritant properties" in PIM (Poisons Information Monographs) G042 (WHO/IPCS, 1996) and HSG (Health and Safety Guides) 70 (WHO/IPCS, 1992).
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description in the humans of arsenic and inorganic arsenics compounds, "gastrointestinal disturbances, neuropathy, effect on blood systems, and disorders on cardiovascular systems, kidney, and liver were observed the long term administration of inorganic arsenic. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow and peripheral nervous systems are also affected " (EHC 224 (2001), and PIM(Poisons Information Monographs) G042 (WHO/IPCS, 1996)), it was classified into Category 1 (a digestive tract, a nervous systems, blood systems, the kidney, liver, respiratory system, skin)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour EC50=78.7microg/L of algae (Scenedesmus) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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