GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：trifluoroarsine
CAS：7784-35-2
Result：
| ID: | 1083 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Non-combustible structurally |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | It was judged as nonflammability by composition. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Considered as non-combustible substances structurally |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it reacts with water and hydrogen fluoride gas occurs, the gas is nonflammable |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | No data available |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There is only a description of the lowest mouse fatal dose 2000mg (= 370ppm)/m3/10m (RTECS, 2004). Saturated concentration is considered to be 130000ppm from vapor pressure of 100mmHg (=13.3kPa) of this substance, and it is presumed to be steam exposure. This lowest lethal doses is converted to 0.4mg/L/4h, and this value is close to the upper limit of Category 1 (0.5mg/L/4h). So LC50 value was thought to be equivalent of Category 2. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | The knowledge of this product was not acknowledged. But from description that an inorganic arsenic compound indicates skin irritation (DFGOT 21, 2005), and that an arsenic compound of 3 values indicates skin corrosivity (HSDB, 2003). So it was judged that this product had mild irritation, and it was set as Category 3. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Although no findings of this product was not observed, due to the description that the fluoride shows eye irritation (ACGIH-TLV, 2005; ACGIH 7th, 2001), it was classified into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | It is not a deterministic conclusion (ATSDR, 2005; HSG, 1992) although there is no knowledge of the quality of a genuine article itself and skin sensitization may be shown to humans as an inorganic arsenic compound, in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Without data. In addition, arsenic and inorganic arsenic compound are classified into the germ-cell mutagenicity category 3A (equivalent for GHS Category 1B-2) in Germany DFG (MAK/BAT, 2005). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004), it was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although the knowledge of this product was not observed, it was considered as Category 2 based on the description related to human of EHC 224 (2001) which is Priority 1 document, about arsenic and arsenic compound, "the effect on reproduction is suggested ", and knowledge of animals "fetus toxicity and teratogenicity in dose in which maternal toxicity is observed". In addition, there is the description that "the conclusion which is inorganic arsenic is not teratogen in humans is advocated " in Catalog of teratogenic agents (2004) equivalent to Priority 1. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) |
|
Danger | H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there was no information about this substance, it was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system). Based on the report that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and based on a similar report in PIM (Poisons Information Monographs) G042 (WHO/IPCS, 1996). In addition, there are reports in ACGIH (7th, 2001) that it affects the liver, upper airways and lungs, and that the fluorides display airway irritant properties (ACGIH-TLV, 2005; ACGIH 7th, 2001). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system, bone) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (digestive system, nervous system, blood system, cardiovascular system, kidney, liver, skin, respiratory system, bone) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Although the knowledge of this product was not observed, the description in the humans of EHC 224 (2001), and PIM(Poisons Information Monographs) G042 (WHO/IPCS, 1996) about arsenic and inorganic arsenics compounds, "gastrointestinal disturbances, neuropathy, affect to blood systems, and disorder of cardiovascular systems, kidney, and liver were observed with the long term administration of inorganic arsenic. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow and peripheral nerves were also affected " and in addition, the descriptioin of the effect on the upper respiratory tract and lungs (ACGIH (7th, 2001)), and fluorides indicates the effect (fluorosis) on respiratory tract stimulative and a bone (ACGIH-TLV, 2005;ACGIH 7th, 2001) . Therefore, it was classified into Category 1 (digestive tract,cardiovascular systems, a nervous systems, the kidney, liver, a blood system, the skin, a respiratory system, bone) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |