GHS Classification Result

Chemical Name：lead hydrogen arsenate
CAS：7784-40-9

Result：
ID: 1078
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (HSDB, 2003)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (HSDB, 2003)
11 Self-heating substances and mixtures Not classified - - - - Not combustible. (HSDB (2003))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble in water)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 1617, Class: 6.1; PG II (Not 5.1).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Between 100mg/kg (RETCS, 2004) and 80mg/kg (HSDB, 2003), the lower level of 80mg/kg was adopted to classify as category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - It seems that it corresponds to Category 5 or outside of Category from rat dermal LD50 value >2400mg/kg (RETCS, 2004). But data is insufficient, it cannot be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From description that produces the redness of the skin (ICSC, 1997), and the inflammation of mucosa and skin (HSDB, 2003), and that stimulates the skin (HSFS, 2001), it was judged that this product had mild irritation, and it was set to Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there are the descriptions that this product irritates to the eye (ICSC, 1997; HSFS, 2001), inorganic arsenic compounds particulate irritates to the eye (HSDB, 2003), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - It is not a deterministic conclusion, although there is no knowledge of this substance and an inorganic lead compound and skin sensitization may be indicated to humans as an inorganic arsenic (ATSDR, 2005; HSG, 1992), in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient.
5 Germ cell mutagenicity Classification not possible - - - - Without data. In addition, arsenic and inorganic arsenic compound are classified into the germ-cell mutagenicity category 3A (equivalent for GHS Category 1B-2) in Germany DFG. Trilead diarsenate (Pb3(AsO4)2, CAS 3687-31-8) which is the one of the lead arsenate is included in it MAK/BAT, 2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004), it was classified into Category 1A.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1A since the potential which indicates reproductive toxicity in humans (ICSC, 1997), and inorganic lead compounds indicate reproductive toxicity to humans (ACGIH-TLV, 2005; ATSDR draft, 2005). In addition, in ACGIH-TLV (2005), for diarsenate trelead (Pb3 (AsO4) 2, CAS: 3687-31-8) which is one of the lead arsenates is supposed that it has serious influences on reproduction.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (digestive system, nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The substance was classified as Category 1 (gastrointestinal system, nervous system) and category 3 (airway irritant). Based on the reports that it affects the gastrointestinal tracts and nervous system and causes irritation to the airways in short-term exposure (ICSC, 1997), that it affects the central nervous system, blood and kidneys in the form of an inorganic lead compound (ACGIH-TLV, 2005), and that it causes gastrointestinal tract symptoms, dysfunctions in the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy in a form of an inorganic arsenic compound (EHC 224, 2001).
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, nervous system, blood system, kidney, liver, respiratory system, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, nervous system, blood system, kidney, liver, respiratory system, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		This product affects a gastrointestinal tract, a nervous system, the kidney, liver, and blood by repeated exposure (ICSC, 1997), a central nervous systems, anemia, and the kidney are affected as one of the lead arsenates which is 2 arsenic acid three lead Pb3(AsO4) 2 [3687-31-8] (ACGIH-TLV, 2005), and there is the description about inorganic arsenic compound that "gastrointestinal tract disorder, neuropathyr, effect on blood system, disorder of cardiovascular system, kidney and liver with long-term oral administration of inorganic arsenic were observed. Target organ are gastrointestinal,heart,brains and kidney. The skin, marrow and peripheral nervous systems are affrected too." (EHC 224, 2001-IM, Poisons Information Monographs G042, WHO/IPCS, 1996), and the description of effect on upper respiratory tracts and lung (ACGIH 7th, 2001), and inorganic lead compounds affect a central nervous system, blood and the kidney (ACGIH-TLV, 2005). Therefore it was classified into Category 1 (a digestive tract, a nervous systems, blood systems, the kidney, liver, respiratory system, skin)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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