GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：trisodium arsenate
CAS：13464-38-5
Result：
| ID: | 1075 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not classified because of UNRTDG No. 1685, Class: 6.1, PG II (not Class: 4.1) though "Flammable" (Sax, 11th, 2004) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not classified because of UNRTDG No. 1685, Class: 6.1, II (not Class: 4.2) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG is classified into 6.1 and II according to the U.N. number (1685) peculiar to a substance. Since 4.2 which indicates self-febrility was not attached, it carried out the outside of Category. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Not classified because of UNRTDG No. 1685, Class: 6.1, PG II (not Class: 4.3) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG No. 1685, Class: 6.1; PG II (Not 5.1). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Without data. [Note] Although Sodium arsenate includes several substances whose molecular formulas differ each other, investigation was conducted by the molecular formula of ASNa3O4 (CAS No.13464-38-5). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | It is not a deterministic conclusion, although there is no knowledge of this product and skin sensitization may be indicated to humans as an inorganic arsenic (ATSDR, draft, 2005; HSG, 70, 1992), in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Without data. In addition, arsenic and inorganic arsenic compound are classified into the germ-cell mutagenicity category 3A (equivalent for GHS Category 1B-2) according to MAK/BAT (2005). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since arsenic and arsenic compound are categorized into human carcinogens in IARC Suppl.7 (1987), ACGIH-TLV (2005), and MAK/BAT (2005), it was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although the knowledge of this product used as classification indicators was not found, in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT vol.21 (2005), there was an opposite report. Since the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated to laboratory animals, it was considered as Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) |
|
Danger | H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system) based on the reports that it affects the kidneys in dogs through intravenous administration (EHC 224, 2001), that in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)), and that it affects the liver, upper airways and lungs (ACGIH (7th, 2001)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since repetition administration to mouse for 28 days and rat for 320 days affect the kidney and liver (EHC 224, 2001), the description of EHC 224 (2001) in human about arsenic and inorganic arsenic compounds "gastrointestinal tract disorder, neuropathy, effect on blood system, disorder of cardiovascular system, kidney and liver with long-term oral administration of inorganic arsenic were observed. Target organ are gastrointestinal, heart, brains and kidney. Skin,marrow and peripheral nerves were also affected " and in addition, based on the description of effect on the upper respiratory tract and lungs (ACGIH (7th, 2001)), it was classified into Category 1 (digestive tract, cardiovascular systems, nervous systems, kidney, liver, blood systems, skin, respiratory system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96-hour EC50=159.3microg/L of algae (Scenedesmus) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |