GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Arsenic acid, hemihydrate
CAS：7774-41-6
Result：
| ID: | 1072 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible (GESTIS-database on hazardous substances, Accessed in Oct. 2006) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (BGIA, GESTIS-database on hazardous substancess, Accessed in Oct. 2006) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible (GESTIS-database on hazardous substances, accessed in Oct. 2006) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (Freely soluble in water) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG No. 1554, Class: 6.1; PG II (Not 5.1). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | There is no data. In addition, HSDB (2005) has description that the anhydride (solution) of the this product "corrode soft steel and brass, etc." |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified as category 2 based on rat LD50 = 48mg/kg (HSDB, 2003;RTECS, 2005) in the oral study. [Notes] Since the toxicity data for health could not be obtained in CAS number 7778-39-4, the toxicity data for health of arsenate and 80% arsenate solution in CAS number 7778-39-4 was described. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
This product was set to Category 2 from description with redness, the pain, and burning sensations which stimulated the skin (ICSC (J), 2005). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
There is the descriptions that this product irritates to the eye, causes redness and pain (ICSC (J) 2005), and the dust of inorganic arsenic irritates to be to upper respiratory tracts and eyes (HSDB, 2003). So it was classified into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Although there is no data of this substance itself, skin sensitization may be indicated to humans as an inorganic arsenic, but it is not a deterministic conclusion (ATSDR, 2005; HSG, 1992), in addition, it was presupposed that it cannot classify from the description in the humans of EHC 224 (2001) "development of the skin sensitization of inorganic arsenic is rare" since data is insufficient. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since it was positive (RTECS, 2005) in the mouse micronucleus assay, it was set as Category 2. In addition, in the in vitro chromosomal aberration test, it is reported the positivity (RTECS, 2005). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since arsenic and arsenic compound are categorized into the human carcinogens in IARC Suppl.7 (1987), ACGHI-TLV (2004), and MAK/BAT (2004), it was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 2 since fetus lethal etc. is seen in the teratogenicity study (oral administration) using a mouse (RTECS, 2005), and in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT Vol.21 (2005), although there was an opposite report, the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated to laboratory animals, so it was set as Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system, blood system) |
|
Danger | H370: Causes damage to organs (digestive system, cardiovascular system, nervous system, kidney, liver, respiratory system, blood system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 (gastrointestinal system, cardio-vascular system, nervous system, kidneys, liver, respiratory system, blood system). Based on the following reports that it can affect blood, cardio-vascular system, gastrointestinal tracts, liver and peripheral nervous system, and causes irritation to the airways (ICSC (J), 2005), in the forms of the arsenic and inorganic arsenic compounds it causes "symptoms in the gastrointestinal organs, disorders in the functions of the cardio-vascular and nervous systems, myelosuppression, alteration in the blood system and nephropathy" in humans (EHC 224 (2001)) and it affects the liver, upper airways and lungs (ACGIH (7th, 2001)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (digestive system, cardiovascular system, nervous system, kidney, liver, blood system, skin, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
This product may affect the peripheral nervous system and the skin, and may occure frequent polyneuropathy and skin injury (ICSC (J), 2005), the description in human (EHC 224 (2001)) about arsenic and inorganic arsenics compounds say "the disorder of gastrointestinal tract, neuropathy, effect on blood systems, and abnormalities of a cardiovascular systems, the kidney, and liver were observed. Target organ are gastrointestinal, heart, brains and kidney. Skin, marrow and peripheral nerves were also affected " , and in addition, based on the description of effect on the top respiratory tract and lungs ( ACGIH (7th, 2001)), it was classified into Category 1 (digestive systems, cardiovascular systems, nervous systems, kidney, liver, blood systems, skin, respiratory system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |