NITE - Chemical Management Field

GHS Classification Result

Chemical Name：copper acetoarsenite
CAS：12002-03-8

Result：


ID:	1071
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (HSDB, 2003)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (HSDB, 2003)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible. (HSDB (2003))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (insoluble in water)
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified	-	-	-	-	UNRTDG No. 1585, Class: 6.1; PG II (Not 5.1).
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	SPECIES: Rat; ENDPOINT: LD50; VALUE: 22 mg/kg; REFERENCE SOURCE: RTECS (2003)
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It is based on rat dermal LD50 value = 2400mg/kg (RTECS, 2003).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	From description that irritation may be indicated in the human skin (SITTIG, 4th, 2002;HSFS, 1999), and description that irritation is indicated as inorganic arsenic compound (HSDB, 2003; DFGOT vol.21, 2005), it was judged that it had slight irritation and it was set as Category 3.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Due to the descriptions that it may irritate to human eye (SITTIG 4th, 2002;HSFS, 1999), and that the dust of this product or arsenic compound shows irritation in human eye with the possibility (HSDB, 2003), it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	It is not firm conclusions although skin sensitization may be shown to humans as an inorganic arsenic compound (ATSDR, 2005; PIM 42, 1996), in addition, the description in the humans "development of the skin sensitization of inorganic arsenic is rare"of EHC 224 (2001), and there is a negative report in a guinea pig examination (maximization test) as an inorganic arsenic compound (ATSDR, 2005; EHC 224, 2001), it was presupposed that it cannot classify according to the shortage of data.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There is only Ames test data (negative) in this material (HSDB, 2003). But chromosome aberration or micronucleus is induced to humans (peripheral blood) or rodents (marrow) as an inorganic arsenic compound (DFGOT vol.21, 2005; EHC 224, 2001; PATTY 5th, 2001; IARC Suppl.7, 1987; IARC 84, 2004; ATSDR draft, 2005), it is set as Category 2. In addition, the inorganic arsenic compound (As+3) was negative in the dominant fatality examination and the mouse energy proto-cell chromosomal aberration test (ATSDR draft, 2005).
6	Carcinogenicity	Category 1A		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The finding of this product is not observed, but inorganic arsenic compound is categorized into human carcinogen in IARC(IARC Suppl.7, 1987; IARC 84, 2004), ACGIH(ACGIH 7th, 2001), DFG(MAK/BAT, 2005), NTP(NTP RoC 11th, 2005). Therefore, it was clasiffied into Category 1A.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although there is no data of this product, in ACGIH (7th, 2001), ATSDR (draft, 2005), EHC 224 (2001), and DFGOT Vol.21 (2005), there was an opposite report. But the reproductive and developmental toxicity knowledge by inorganic arsenic was indicated to laboratory animals, it was considered as Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system), Category 2 (digestive system, cardiovascular system), Category 3 (respiratory tract irritation)		Danger Warning	H370: Causes damage to organs (nervous system) H371: May cause damage to organs (digestive system, cardiovascular system) H335: May cause respiratory irritation (respiratory tract irritation)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Although there are no data for this substance, the substance was classified as Category 1 (nervous system), Category 2 (gastrointestinal system, cardio-vascular system) and Category 3 (airway irritant). Because there are reports of the effects of the substance itself on the nervous system (EHC 224, 2001), of the effects of the substance in the form of an inorganic arsenic compound on the gastrointestinal system, cardio-vascular system and nervous system (EHC 224, 2001; HSG 70, 1992), and also of airway irritant properties (HSDB, 2003; HSG 70, 1992; HSFS, 1999).
9	Specific target organ toxicity - Repeated exposure	Category 2 (skin, digestive system, nervous system, lung, liver, cardiovascular system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (skin, digestive system, nervous system, lung, liver, cardiovascular system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Although there is no data of this product itself, since it effects on the skin, a gastrointestinal, nervous systems, lungs, liver, and a cardiovascular system by an inorganic arsenic (EHC 224, 2001;HSG 70, 1992), it was classified into Category 2 (the skin, a gastrointestinal, a nervous systems, lungs, liver, cardiovascular system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=286microg/L of fishes (Coho salmon) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）