GHS Classification Result

Chemical Name:cadusafos
CAS:95465-99-9

Result:
ID: 1070
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - In 25 degC, it is stable under neutral or weak acidity. (Agricultural Chemical Registration Data)
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was categorized as category 2 based on the value of LD50=30mg/kg. This value was calculated from LD50 value in two oral toxicity examinations (Agricaltural Chemical Registration Data).
1 Acute toxicity (Dermal) Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 based on rat LD50 = 11mg/kg of the dermal toxicity tests (Agricultural Chemical Registration Data).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 based on rat LC50 (4 hours) = 0.026mg/L of the inhalation toxicity study (Agricultural Chemical Registration Data).
2 Skin corrosion/irritation Not classified - - - - In the primary skin irritation examination of the rabbit, based on the statement that irritation is not admitted (Agricultural Chemical Registration Data), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - There is the description that in the eye irritation examination using rabbit, corneal opacity and chemosis of conjunctiva were not observed. And the average score of iritis and conjunctival redness was 0.5, but it disappeared 48 hours after (Agricultural Chemical Registration Data). So it was out of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
By the examination of the Maximization method by the guinea pig, it was referred to as Category 1 based on the publication (Agricultural Chemical Registration Data) with those with skin sensitization.
5 Germ cell mutagenicity Not classified - - - - There is no data of human administration cost epidemiology, administration cost mutagenicity test, and germ cell in vivo mutagenicity test. And the negative result was obtained by the somatic cell in vivo mutagenicity test (in vivo chromosomal aberration test using rat myeloid cells) (Agricultural Chemical Registration Data). So it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - In the test using mice and rats, based on the description of carcinogenicity was not obsderved in each case (Agricultural Chemical Registration Data), it was out of Category.
7 Reproductive toxicity Not classified - - - - It was considered as the outside of Category based on the description that the influence on the teratogenicity and reproduction resulting from administration of this product and all of reproduction toxicity are not observeed in the two-generation reproductive examination using rat, and the teratogenicity study using rat and rabbit (Agricultural Chemical Registration Data).
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity, nervous system) Danger H370: Causes damage to organs (systemic toxicity, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Symptoms, such as lacrimation, decrease in locomotor activity, salivation, tremors, loss of muscle strength, dyspnea, hypersensitivity, bloody tears, hematuria, fur loss and colored nasal discharge, were observed in an acute oral toxicity test in rats and mice, but all the animals recovered (Agricultural Chemical Registration Data). The substance was classified as Category 1 (systemic, nervous system) because these symptoms appeared at dosages (30-82mg/kg) within the guidance values for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (systemic toxicity) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a rat, there is a description that decrease in cholinesterase was observed with the dose (0.327 mg/kg) within the range of guidance value in Category 1. Moreover, there is description of debility, decreased locomotor activity, hind limbs open legs and tremors with the dose (59.1 mg/kg) of guidance value within the range of Category 2 (Agricultural Chemical Registration Data). It was classified into Category 1 (nervous systems) and Category 2 (systemic) based on these.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour LC50=0.0016mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 1999).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.9(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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