Chemical Name:nicotine sulphate
CAS:65-30-5
ID: | 1069 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Not classified | - | - | - | - | Not classified because of UNRTDG No. 1685, Class: 6.1, PG II (not Class: 4.1) though "Flammable" (Sax, 11th, 2004) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Not classified because of UNRTDG No. 1658, Class: 6.1, II (not Class: 4.2) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG is classified into 6.1 and II according to the U.N. number (1658) peculiar to this substance. Since 4.2 which indicates a self-febrility chemistry article was not attached, it carried out the outside of Category. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Among rat LD50 = 50mg/kg (RTECS(2003)) and 83mg/kg (HSDB(2003)), the lower value (50mg/kg) was adopted to classify as category 2. [Note] In addition, also refer to nicotine (ID 608, CAS:54-11-5) about healthy hazards. | |
1 | Acute toxicity (Dermal) | Category 1 | Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Rat LD50 = 285mg/kg , and rabbit LD50 = 50mg/kg (both are RTECS (2003)). The lower value of rabbit LD50 value was adopted, and it was set as Category 1. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
In Priority 2, since there was description which indicates irritation to human skin (ICSC (J), (1997), SITTIG (4th, 2002), HSFS (2002)), it was set as Category 2. | |
3 | Serious eye damage/eye irritation | Category 2A-2B | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
In Priority 2, since there is the description which indicates irritation to the human eye (ICSC (J), (1997), SITTIG (4th, 2002), HSFS (2002)), it was classified into Category 2A-2B. In addition, it is difficult to subdivide the Category of this data. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | The result of the patch test using this material to the vegetable producer who produced the dermatitis by agricultural chemicals in Priority 2, there is a report that 10-28% of people showed susceptibility (HSDB(2003)), it is only one example, and data of a report is insufficient and it cannot classify. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
This product was also considered as Category 2 as well as nicotine, since head facial anomaly are seen by the intraperitoneal injection into pregnant mice of this product (RTECS (2003)), there is description "it is shown in the animal experiments that it may have toxic effects on human reproduction" (ICSC (J) (1997), SITTIG (4th, 2002), HSFS (2002)), the affect on reproduction by nicotine (ID 608, CAS: 54-11-5) was suggested. Refer to the reproductive toxicity of nicotine (ID 608, CAS: 54-11-5). | |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system), Category 3 (respiratory tract irritation) | Warning |
H371: May cause damage to organs (central nervous system) H335: May cause respiratory irritation (respiratory tract irritation) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
The substance was classified as Category 2 (central nervous system) and Category 3 (airway irritant). Because it is reported in Priority 2 that it affects the central nervous system in humans (ICSC (J) (1997), SITTIG (4th, 2002)), and that inhalation of it causes irritation to nose and throat (SITTIG (4th, 2002)). It is also reported that nicotine has irritant properties to the peripheral autonomic nervous system and the nerve terminals of skeletal muscle (Refer to nicotine (ID608, CAS: 54-11-5). | |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48-hour EC50=3250microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2, since acute toxicity was Category 2, and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=0.4(PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |