Chemical Name：2-chloro-1-phthalimidoethyl O,O-diethyl phosphorodithioate
CAS：10311-84-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Considering the data of LD50= 21mg/kg obtained from statistical processing of 6 rat data of JMPR(Joint Meeting on Pesticide Residures-Monographs&Evaluations)363 (WHO/IPCS, 1976), which was equivalent to Priority 1, it was classified as category 2.
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 baced on rabbit LD50 = 145mg/kg (JMPR(Joint Meeting on Pesticide Residures-Monographs&Evaluations)363 (WHO/IPCS, 1976) equivalent to Priority 1).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Not applicable	-	-	-	-	The vapor pressure of this product is very low, and it was thought that steam exposure was almost impossible. Therefore it was out of classification.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	From rat LC50 = 0.13mg/L of JMPR(Joint Meeting on Pesticide Residures-Monographs&Evaluations)363 (WHO/IPCS, 1976) equivalent to Priority 1, it was set as Category 2.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	There is description that indicate minor irritation to the result of 2 examinations of the rabbit (slight irritation) (JMPR(Joint Meeting on Pesticide Residures-Monographs&Evaluations)363 (WHO/IPCS, 1976)), and it was set as Category 3.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	There is the description of slight stimulative in the examination of rabbit (Mild irritation) (JMPR (Joint Meeting on Pesticide Residures - Monographs & Evaluations)363(WHO/IPCS, 1976)), it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data
6	Carcinogenicity	Not classified	-	-	-	-	There are two reports of the carcinogenicity test in rats for two-year administration in JMPR(Joint Meeting on Pesticide Residures - Monographs & Evaluations)363(WHO/IPCS, 1976) coresponding to Priority 1, and no finding of tumorigenesis was observed in each report (the number of animals was small in one report). Therefore, it was out of the Category 1.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There are 5 reports of reproduction toxicity studies in JMPR (Joint Meeting on Pesticide Residures-Monographs & Evaluations) 363 (WHO/IPCS, 1976), RTECS (2003), and HSDB (2003), and in treatment groups, the rise of embryo and fetus lethality, and deformed generating are described. These are not necessarily dosage dependence. And it is considered that in one case of JMPR, the toxicity of chemicals is not the main causes for increased mortality of embryonic and fetus. Since any data did not have the descriptions on general toxicity of parent animals and reproductive toxicity had been manifestation. So it was considered as Category 2.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 2 (nervous system) based on the reports about the effects in humans in SITTIG (4th, 2002) and HSDB (2003), which are priority 2 references. (The substance inhibits cholinesterase, and causes various systemic symptoms resulting from its neurotoxicity.)
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	We classified it into Category 1 (the nervous systems, liver) based on the description of JMPR (Joint Meeting on Pesticide Residures-Monographs & Evaluations) 363 (WHO/IPCS, 1976; equivalent to Priority 1) in rats and human.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since a potential that relevant toxicity was discovered in the water solubility (0.18 mg/L(PHYSPROP Database, 2005)) of this substance cannot be denied from 96-hour LC50=1.80-8.30mg/L of fishes (Goldfish) (HSDB, 2004), it was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.69 (PHYSPROP Database, 2005)).