NITE - Chemical Management Field

GHS Classification Result

Chemical Name：mercury dicyanide
CAS：592-04-1

Result：


ID:	1039
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (NFPA, 13th, 2002)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (NFPA, 13th, 2002)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Non-combustible (NFPA, 13th, 2002)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (the water solubility is obtained)
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Inorganic compounds containing no oxygen and halogen.
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE:26mg/kg; REFERENCE SOURCE: RTECS (2006)
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	There is description that the skin is stimulated (HSDB (2005), HSFS (1993), and SITTIG (4th, 2002)), and it was set as Category 3.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since there is the description that it stimulates to eyes (HSDB (2005), HSFS (1993), and SITTIG (4th, 2002)), it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	In MAK/BAT (2005) and JSfOH advice (2005), mercury and mercury compounds was supposed to have risk of cutaneous sensitization. Since we found the descriptions that skin sensitization may be caused also in HSFS (1993) and SITTIG (4th, 2002) about this product, we categorized it as Category 1.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Without data. In addition, it is supposed that there is no mutagenicity in metal mercury (CICAD (J), 50, 2003) and cyanide (CICAD (J), 61, 2004; PIM G003, WHO/ICPS, 1997).
6	Carcinogenicity	Classification not possible	-	-	-	-	The inorganic mercury compound is classified into Group 3 in IARC 58 (1993) and A4 in ACGIH-TLV (2006). Although all were equivalent to out of Category, a suitable carcinogenicity test about cyanide was not conducted (CICAD (J), 61, 2004 ;PIM, G003, WHO/ICPS, 1997). And it was considered that it couldnot be classified due to the lack of data of the product.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although there is no data of this product, the inorganic mercury compound is a developmental toxicologies substance by father exposure (natural abortion in humans is reported ) in Chemically Induced Birth Defects (3rd, 2000) of classification guidelines reference. Since generating toxicity was observed also in California Proposition 65 (2005), it was considered as Category 1B. In addition, "it is suggested that mercury element or an inorganic mercury compound is not developmental toxic substances at the dose which does not give toxicity to the maternal" (CICAD (J) 50, 2003), and also there are description that "cyanide induces detrimental effect against development only by the given dose or concentration which has toxicity in dam clearly" (CICAD (J), 61, 2004).
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system, respiratory system, central nervous system, kidney)		Danger	H370: Causes damage to organs (cardiovascular system, respiratory system, central nervous system, kidney)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	There are no data for this substance. But CICAD (J) 61(2004), a Priority 1 document, lists the cardio-vascular system, respiratory system and central nervous system as the target organs of the cyanide of the substance in acute toxicity tests. The substance was classified as Category 1 (cardio-vascular system, respiratory system, central nervous system, kidneys) because it is reported in CICAD 50 (2003) that effects of the inorganic mercury compound on the kidneys are observed in acute toxicity tests in humans and animals.
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the description that central nervous systems and kidney are affected by inorganic mercury compounds ( CICAD(J)50 (2003) and ACGIH-TLV (2006) (both of which are the Priority 1 document)) and that in repeated exposure of cyanide affects the central nervous systems, too (CICAD (J) 61 (2004), and HSFS (1993; Priority 2 document) also has the same statement by this product, therefore we classified it into Category 1(central nervous systems, kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=20microg/L of Crustacea (Daphnia magna) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）