GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：phosphamidon
CAS：13171-21-6
Result：
| ID: | 1019 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data on its flash point; etc. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (miscible in water) |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | No data available |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
SPECIES: Rat ENDPOINT: LD50 VALUE: 17 mg/kg REFERENCE SOURCE: PIM(Poisons Information Monographs)454, WHO/IPCS (2001) |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was based on rat LD50 value of 374mg/kg (PIM(Poisons Information Monographs) 454, World Health Organization/IPCS, 2001). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The vapor pressure of this product is 0.0033Pa (20degC). Saturated vapor pressure pressures concentrations was calculated with 0.03ppm, and 0.102mg/L was 8.3ppm, it imagined it as mist. Based on rat LC50 value: 0.102mg/L/4h, 0.135mg/L/4h, 0.16mg/L/4h (all are PIM(Poisons Information Monographs) 454, WHO/IPCS, 2001), the category was carried out with calculation. LC50 = 0.105mg/L/4h. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There is the description about the human eye stimulativeness that "Most of the 32 persons felt the irritant property of the conjunctiva immediately after application"(PIM (Poisons Information Monographs) 454 (WHO/IPCS, 2001)). So we classified it as Category 2. However, the data was insufficient, so deliberate categorization of 2A and 2B was impossible. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Since the data was insufficient, we could not classify it. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There are two or more positive reports from the data of RTECS(2004) and HSDB(2004) in the in vivo marrow chromosomal aberration test of a rat and a mouse, and it is negative in the chromosomal aberration test with a mouse spermatocyte. So it is set as Category 2. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Since it can be considered that there is no clear evidence of tumor formation in rat and mouse based on the description "Male Rats:Equivocal of HSDB (2004) (former literature is NTP TR16 and 1979), Female Rats:Equivocal, Male Mice:Negative, and Female Mice:Negative". So it was considered as the outside of Category . |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Although in the laboratory-animals data (a teratogenicity study, 2generation reproduction study) of HSDB (2004) and Toxicology Data Review Summaries (California EPA/Dept.of Pesticide Regulation, 1990), decrease in fetus weight was seen, but in PIM (Poisons Information Monographs) 454 (WHO/IPCS, 2001), there is the knowledge in the humans"pregnancy is continued without being influenced, and normal child was born", it was thought that there was no reproductive toxicity in humans, and it was considered as the outside of Category. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory system, cardiovascular system) |
|
Danger | H370: Causes damage to organs (nervous system, respiratory system, cardiovascular system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 (nervous system, respiratory system, cardio-vascular system) based on the report in humans, "the target organs are nervous system, respiratory system and cardio-vascular system"(PIM (Poisons Information Monographs) 454 (WHO/IPCS, 2001), which is equivalent to Priority 1). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
We classified it into Category 1 (nervous systems) based on the Priority 1-equivalent PIM (Poisons Information Monographs) 454 (WHO/IPCS, 2001) and the description about the possibility in human, "effect on the central nervous system" and"cholinesterase inhibitors: it has accumulation effect" of ICSC(1995) of Priority 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour EC50=0.01mg/L of Crustacea (Water flea) (HSDB, 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.79(PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |