GHS Classification Result

Chemical Name：1-Naphthylamine
CAS：134-32-7

Result：
ID: 1015
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG Class: 6.1
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 460degC (ICSC (J), 2000)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value = 680mg/kg (IUCLID (2000), HSDB (Access on Oct 2005)) and 779mg/kg (IUCLID(2000)). Based on the data above, it was classified as category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rat LD50 value = 447mg/kg (IUCLID (2000), HSDB (Access on Oct 2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is the data stating that rat LC50 (4 hours) value was >0.056mg/L (IUCLID (2000), HSDB (Access on Oct 2005)). But it was not able to judge whether it would correspond to Category of except for category 1 from this data.
2 Skin corrosion/irritation Not classified - - - - Although a potential of stimulating the skin slightly as effect of short-term exposure to humans is suggested (HSDB (Access on Oct 2005), HSFS (2004) and ICSC (J) (2000)), there is no case reports. On the other hand, there was description that irritation was not admitted by the test which used the rabbit (IUCLID (2000), HSDB (Access on Oct 2005)). So it was set as the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		We classified it as Category 2B based on the descriptions that mild irritation was acknowledged in the tests using the rabbits (IUCLID (2000) and HSDB (Access on Oct 2005)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although the result was indicated as sensitizing in Maximization test which used the guinea pigs in IUCLID (2000), we presupposed that we could not categorize it according to the technical guidelines since the ratio of the animals in which sensitization was observed was not indicated.
5 Germ cell mutagenicity Not classified - - - - It was negative in the micronucleus test which used the mouse, which is an in vivo mutagenicity test using a somatic (IUCLID (2000)). So it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into 3 in IARC (Access on Oct 2005), it was considred as the outside of Category. [special notes] Although the carcinogenic of the product is not clear, beta-naphthylamine which is constitutional isomer of the product has carcinogenic for humans (it was classified into a group 1 in IARC. 2005). Therefore, it needs to be careful that the product may have beta-naphthylamine as impurities.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (blood) Warning H371: May cause damage to organs (blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was judged that the target organ of this substance was blood. Because there is a report in PATTY (4th, 1994) that methemoglobin is formed at the forced oral dosage of 200mg/kg in dogs, although there are no specific case reports in humans, there are reports of possible methemoglobinemia in the reference, Priority 2 (HSDB (Access on Oct 2005), ICSC (J) (2000), HSFS (2004), SITTIG (4th, 2002)). So the substance was classified as Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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