GHS Classification Result

Chemical Name：Butadiene, hexachloro-
CAS：87-68-3

Result：
ID: 1012
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible (Category 4 or Not classified) - Warning H227: Combustible liquid - The data obtained from materials are deviated. Therefore, if flash point and initial boiling point (can be substituted with boiling point) are not measured with an actual sample, it cannot be judged. The acceptance criteria are as follows: Category 4: 60-degC< flash point <=93 degC; out of Category: flash point >93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 6.1
9 Pyrophoric liquids Not classified - - - - Flash point: 610degC (ICSC (J), 1997)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 value: 350mg/kg (EHC 155, 1994; ACGIH 7th. 2001; PATTY 4th., 1994), 250mg/kg (EHC 155, 1994; IARC 20, 1979), 200mg/kg and 46mg/kg (each EHC 155, 1994; PATTY 4th. 1994; ATSDR, 1994), 200mg/kg (EHC 155, 1994; PATTY 4th., 1994). Calculated based on the data above. Based on the calculated LD50 value of 128 mg/kg, it was classified as category 3.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on rabbit LD50 value: 1120mg/kg (EHC 156, 1994; ATSDR, 1994), it was set as Category 4.
1 Acute toxicity （Inhalation: Gases） Classification not possible - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on mouse LC50 value (6 hours): 0.107mg/L (4 hour equivalent: 0.131mg/L (about 12.3ppm) (EHC 156, 1994)) which indicates steam with almost no mist from its vapor pressure. And it was classified as Category 1 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		We judged that there was skin sensitization property based on the description that the positive rate was 100% in the test {EHC 156 (1994)} using the guinea pigs, we classified it to be Category 1.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although it is negative in dominant lethal test using the rat which is multigeneration mutagenicity test using a germ cell (ATSDR, 1994), it is positive in oral administration and inhalation exposure by the chromosomal aberration test using the mouse marrow cell using a somatic cell, which is the in vivo mutagenicity test (EHC, 156, 1994), and there is no productive cell in vivo examination. So it is set as Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into a group 3 in IARC (73, 1999), C in EPA (IRIS, 1991 evaluations), and A3 in ACGIH (7th.2001). It is considered as Category 2 based on the classification of ACGIH which is latest assessment.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2 since in the perinatal period medication examination (feed-mix administration from pregnancy the 17th to after-delivery the 10th) of the rat, nephrotoxicity was acknowledged also in fetus by the dose nephrotoxicity etc. is observed in dam (NTP DB, 2006).
8 Specific target organ toxicity - Single exposure Category 1 (kidney) Danger H370: Causes damage to organs (kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (kidneys) based on the reports of kidney tubular degeneration in an inhalation exposure test in mice after 4 hours of exposure at a concentration within the guidance values of Category 1(EHC 156, 1994; ATSDR, 1994), and of kidney tubular necrosis in a percutaneous exposure test in rabbits at the non-lethal dose of 388mg/kg (EHC 156, 1994; ATSDR, 1994).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, bone marrow) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, bone marrow) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		We classified it into Category 1 (liver, kidney, marrow) based on the description that in oral administration in the rat for 3-week to two-year, the denaturation, necrosis and tissue reproduction were observed in renal proximal tubule with the dosage of the guidance value range of Category 1 ((EHC 156, 1994, ACGIH 7th.2001) PATTY (4th. (1994), NTP DB (2006), and ATSDR (1994)), based on the description that the same disorder was observed also in the two-week to three-month oral study with the mouse (PATTY 4th.1994), and based on the description that in the study in feeding administration to rats and mouse with the dosage of guidance value range of Category 1, the swelling of the cell, the rise of aggregation of a basophil granule, a necrosis, and serum GPT activation in the liver were observed, and the description that in the feeding administration study for two weeks to a mouse, marrow hematopoietic cell decreases was observed with the dosage of guidance value range of Category 1 (EHC 156, 1994, ACGIH 7th.2001). PATTY (4th. (1994), NTP DB (2006), and ATSDR (1994).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=32microg/L of Crustacea (Mysid shrimp) (CaPSAR, 2001).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 24% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=9240 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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