GHS Classification Result

Chemical Name：tris(2,3-dibromopropyl) phosphate
CAS：126-72-7

Result：
ID: 1009
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value: 5.24g/kg (EHC 173, 1995; IARC 20, 1979), 1.88g/kg and 3.12g/kg (all data from EHC 173, 1995) and 810mg/kg (MOE Risk Assessment the 3rd volume, 2004). Calculated based on the data above. It was classified to category 4 based on the acquired calculated value of 1202mg/kg.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50: 17.6g/kg (EHC173, 1995) and >8g/kg (EHC173, 1995;IARC 20, 1979), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on description without irritation by the skin irritation test using a rabbit (EHC 173, 1995;IARC 20, 1979-ATTY 4th, 1994), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - Based on the descriptions that it showed no irritant property in the eye irritation tests applied to the eyes of the rabbits (EHC 173 1995; IARC 20, 1979-ATTY 4th, 1994), we classified it as Out Of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the description that skin sensitization property was not acknowledged (EHC 173, 1995; IARC 20, 1979; PATTY 4th, 1994) in the Landsteiner method (Modified Landsteiner Methods) using the guinea pigs, and based on the several sorts of reports which examined skin sensitization in human, potential of skin sensitization to the humans of this substance was evaluated to be low (EHC 173, 1995), therefore we classified it to be Out Of Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is no in vivo mutagenicity test data using a germ cell, it is negative in the chromosomal aberration test using the rat marrow cell which is the in vivo mutagenicity test using a somatic, and it is indicated that the hamster is positive and the mouse is weakly positive in the small core examination which used the hamster and the mouse (all are EHC 173, 1995;IARC 20, 1979; IARC 71, and 1999). But there was no data of the in vivo heredity toxicity examination by the productive cell. So it is set as Category 2. In addition, in the DNA damage examination and in vitro mutagenicity test using a somatic which are in vivo genotoxicity studies, the examination data of the other kinds in which a positive is indicated is obtained (EHC 173, 1995;IARC 20, 1979;IARC 71, 1999).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was classified into group 2A in IARC (IARC 71, 1999), 2A in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005), and R in NTP, it was considered as Category 1B.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are effects on male genitalia that it is observed that decreased weight of testis, epididymis and prostate, atrophy, reduction of spermatogenesis ability, decrease germ cell count of tubulus seminiferus contortus and reduction of sperm motility in male rat repeated intraperitoneal injection test (30 times/72 days), and that increase of abnormal spermatozoa in male rat after 5-days intraperiotoneal injection and 35 days breeding (all are EHC 173 and 1995). On the other hand, it was classified into Category 2 based on the description that there is increases of skeletal mutation but no teratogenecity and fetal dysgenesis at dose causing general toxicity to maternal animals to pregnant rat oral administration test in fetal period of organogenesis (EHC 173, 1995;IARC 70, 1999).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		We classified it into Category 2 (kidney) based on the description that in the 90-days repeated oral administration test of a rat, chronic nephritides, such as the denaturation, hyperplasia, and dysplasia of the kidney nephric tubule epithelial cells was observed with the dosage of the guidance value of Category 2 (EHC 173, 1995).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour EC50=3100microg/L of algae (Scenedesmus) (MOE Risk Assessment No.3, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 2% (existing chemical safety inspections data)), though less bio-accumulative (BCF=4.3 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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