GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Di-Butyl phenyl phosphate
CAS：2528-36-1
Result：
| ID: | 1005 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Flash point: >93degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible | - | - | - | - | No data available |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | No data available |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | SPECIES: Rat ENDPOINT: LD50 VALUE: 2620 mg/kg REFERENCE SOURCE: ACGIH (7th, 2001) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rabbit LD50 value: >5000mg/kg (ACGIH 7th, 2001), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | From description that irritation was not acknowledged by exposure for 24 hours in the test using the rabbit on ACGIH (7th, 2001), it was carried out the outside of Category. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Based on the description that it did not show irritant property in the test applied to the eyes of the rabbits (ACGIH (7th, 2001)), we classified it as Out Of Category . |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | There was description that based on the result of the patch test for humans, it is thought that there was no sensitizing in ACGIH (7th, 2001), however, sensitizing property was not negated clearly and there was also no animal test data, therefore we presupposed that we could not classify since data is insufficient for considering it to be Out Of Category. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Since there is a negative result (ACGIH 7th, 2001) by the chromosome aberration test using the rat marrow cells which are the in vivo mutagenicity tests using a somatic, it carried out the outside of Category. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Although there is description that teratogenic and fetus toxicity were not observed in the oral administration study using the pregnancy rat (ACGIH (7th, 2001)), since in this study, the general toxicity in parent animals is not observed, it was not sufficient data to be as out of Category. So it cannot be classified due to insufficient data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no specific case reports, the substance was classified as Category 3 (airway irritant) because of the report that it caused irritation to nose and throat (ACGIH (7th, 2001)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, urinary bladder, ovaria, blood) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, urinary bladder, ovaria, blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
We classified it into Category 2 (liver, a bladder, ovary, blood) based on the description that in the feeding oral administration tests during 90 days using the rat, the influence on the liver, a bladder, the ovary, and blood was observed with the dosage of the guidance value range of Category 2 (ACGIH (7th, 2001)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour LC50=0.26mg/L of Crustacea (Daphnia magna) (ECETOC TR91, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD of di-n-butyl phosphate: 2% (existing chemical substances safety inspections data)), and bioaccumulative (log Kow=4.27 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |