GHS Classification Result

Chemical Name:2-Propanol, 1-(2-methoxypropoxy)- ; Dipropylene Glycol Methyl Ether
CAS:13429-07-7,34590-94-8

Result:
ID: 994
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 270degC (ICSC (J), 1999)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Not classified because of SPECIES: Rat; ENDPOINT: LD50; VALUE: :5350mg/kg (ACGIH 7th, 2001), 5400mg/kg (SIDS, 2001), 5100mg/kg (ACGIH 7th, 2001), 5180mg/kg (ACGIH 7th, 2001; PATTY 4th, 1994; SIDS, 2001)
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50 values: 9500mg/kg (ACGIH 7 th2001, SIDS2001), 13000 - 14000 mg/kg (DFGOT vol. 6, 1994, SIDS, 2001), 10100mg/kg (DFGOT vol. 6, 1994, SIDS, 2001), >19000mg/kg (SIDS, 2001), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that irritation was not admitted in the test applied to the skin of the rabbit (ACGIH (7th, 2001) and SIDS (2001)), and from description that irritation was not admitted in the test applied to the skin of the humans (ACGIH (7th, 2001), DFGOT (vol.6, 1994), PATTY (4th, 1994) and SIDS (2001)), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
We classified it as Category 2B based on the description that mild corneal irritation was acknowledged in the test applied to the eyes of the rabbits (ACGIH (7th, 200)1).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was description that sensitizing property was not acknowledged in the patch test for 250 examples in ACGIH (7th, 2001), DFGOT (vol.6, 1994), PATTY (4th, 1994), and SIDS (2001), we have no animal test data and there was also no description which negates sensitizing property clearly, therefore we presupposed that it is considered lack of data and could not classify it to be Out Of Category.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - There is a description in PATTY (4th, 1994) and SIDS (2001) that reproductive toxicity was not observed in the inhalation exposure test using pregnant rats and rabbits. However, since these examinations are carried out by the dose in which general toxicity is not observed in parental animals, the data was not enough evidence to classify it as outside of classification. Therefore, since the data is insufficient, it cannot be classified.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 3 (airway irritant, anesthetic properties) based on the reports that anaesthetic properties were observed in percutaneous administration tests using rabbits and oral and inhalation administration tests using rats, and airway irritation in human exposure cases (ACGIH (7th, 2001), DFGOT (vol.6, 1994), PATTY (4th, 1994) and SIDS (2001)).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - We classified it as Out Of Category based on the description that the serious toxic effect was not observed in inhalation exposure, oral administration, or a dermal administration test using rats, rabbit, or mouse with the dose which exceeds the guidance value range of Category 2 (ACGIH (7th, 2001), DFGOT (vol.6, 1994), PATTY (4th, 1994) and SIDS (2001)) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour LC50=1919mg/L of Crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (miscible with water (SIDS, 2004)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations


To GHS Information