GHS Classification Result

Chemical Name：2-Heptanone
CAS：110-43-0

Result：
ID: 985
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 393degC (ICSC (J), 1996)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on the rat LD50 value: 1670mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994), 2407mg/kg (PATTY 4th, 1994) and approximately 1600mg/kg (PATTY 4th, 1994). Since the calculation value was lower than 1600mg/kg which was the lowest value, 1600mg/kg was adopted to classify as category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value: 12.6mL/kg (PATTY 4th, 1994) (reduced values = 10300mg/kg), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There are the description that death was not observed with rat 4-hour inhalation exposure to 2000ppm (vapor with almost no mist from its vapor pressure) (PATTY (4th, 1994)), and that all 6 rats died from exposure to 4000ppm (vapor with almost no mist from its vapor pressure). By the ppm concentration standard, it was presupposed that it cannot be classified although it is considered to be either Category 3 or Category 4.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is the description that the all three rat died from 5100ppm (equivalent 23.8mg/L) within 4 hours in the inhalation exposure test (PATTY (4th, 1994)). But there is no other data. Therefore, it cannot be classified since data is insufficient for specifying category.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that the moderate irritation was admitted in the test applied to the skin of the rabbit for 24 hours (ACGIH (7th, 2001) and PATTY (4th, 1994)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Change of the eyes which corresponds to the standard of irritation was not admitted in the eye irritation tests using the rabbit (ECETOC TR48 (1992)). However, there is the description that slight irritation was acknowledged in the eyes of the rabbits (PATTY (4th, 1994)). So we classified it as Category 2B
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was description that it gave no positive reaction in the skin sensitivity test for humans in PATTY (4th, 1994), subjects of this small-scale test were 26 examples and since there was no other data, we presupposed that it is considered lack of data and we could not classify it.
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of descriptions in ACGIH (7th, 2001) and PATTY (4th, 1994) referring to that respiratory irritant and anesthetic actions were confirmed in inhalation exposure tests using guinea pigs, and of a description in PATTY (4th, 1994) referring to confirmation of respiratory irritant and anesthetic actions (symptoms indicating effects on nervous systems) in an inhalation exposure test using rats, it was judged as Category 3 (respiratory irritation, anesthesia action).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Based on the descriptions that no effect was observed with the concentration exceeding the guidance value range for Category 2 in the nine-month inhalation exposure test on rats (ACGIH (7th, 2001) and PATTY (4th, 1994)), and that no effect was observed with the dose exceeding the guidance value range for Category 2 in the repetitive oral administration test on rats (PATTY (4th, 1994)), it was classified as out of Category.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of a ketone composed of 13 carbon atoms or less.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50=131mg/L of fishes (Fathead minnows) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =4300mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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