GHS Classification Result

Chemical Name:methyl cyclopentadienyl manganese tricarbonyl
CAS:12108-13-3

Result:
ID: 978
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible (Category 4 or Not classified) - Warning H227: Combustible liquid - If the information with 93 degC (Weiss (2nd, 1986) p.692) is adopted, it will be classified as Category 4, but there are multiple data with more than 93 degC. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: Category 4: 60-degC< flash point <=93 degC; out of Category: flash point >93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Rat LD50 value: 58mg/kg (ACGIH 7th, 2001, NICNAS, 2003, EHC 17, 1981), 22.9mg/kg, 16.8mg/kg, 50mg/kg, 23 - 176 mg/kg and 9->80mg/kg (NICNAS, 2003), 175mg/kg and 89mg/kg (EHC 17, 1981). Calculated based on the data above. Since the calculated values was 39.9mg/kg, it was classified to category 2.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3. Based on the value of 212.7mg/kg calculated from rabbit LD50 values: 140mg/kg and 795mg/kg (ACGIH 7th, 2001, NICNAS, 2003), 196.7mg/kg and 420mg/kg (NICNAS, 2003), 1350mg/kg (NICNAS, 2003, PATTY 4th, 1994, EHC 17, 1981), and rat LD50 value: 665mg/kg (NICNAS, 2003, PATTY 4th, 1994, EHC 17, 1981).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculated based on rat LC50 (4 hours) : 0.076mg/L (ACGIH 7th, 2001, NICNAS, 2003), LC50 (1 hour) : 0.247mg/L (4-hour equivalent: 0.124mg/L) (ACGIH 7th, 2001, NICNAS, 2003), LC50 (1 hour) : 0.22mg/L (4-hour equivalent: 0.11mg/L) (NICNAS, 2003). Since the calculated value was 0.08mg/L, it was classified as Category 1.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is description that there was no irritation in single contact to the human cutaneous (ACGIH (7th, 2001)). But it was set as Category 3 from description that slight irritation was admitted in the skin irritation test using the rabbit (NICNAS (2003)).
3 Serious eye damage/eye irritation Not classified - - - - In the test applied to the eyes of the rabbits, the change of the eyes applicable to 1-3 of the stimulative judging standard was not acknowledged (NICNAS (2003)). Therefore we classified it as Out Of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Since data was insufficient, we could not classify it.
5 Germ cell mutagenicity Not classified - - - - There is a negative result by the dominant lethal test using the mouse which is an in vivo multigeneration mutagenicity test using a germ cell (NICNAS, 2003), and the micronucleus test which used the mouse erythrocyte, which is the in vivo mutagenicity test using a somatic (NICNAS, 2003). So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that clear reproductive toxicity was not observed even at the dose in which the significant inhibit weight gains is observed in a mother animal in an oral administration examination during the pregnancy using the rat (NICNAS (2003)).
8 Specific target organ toxicity - Single exposure Category 1 (lung), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (lung)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was judged as Category 1 (pneumoconiosis) because of a description in NICNAS (2003) referring to confirmation of effects on lungs at a given dose within the guidance value of Category 1 in oral administration studies using rats. Moreover, because of descriptions for human exposure cases in ACGIH (7th, 2001) and NICNAS (2003) referring to that conditions, such as temporary giddiness, nausea, and headache, were confirmed. So it was judged that there were anesthetic actions, and determined to be Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified into Category 2 (liver, kidney) duing to description that the effects on the liver and kidney were observed with the exposure concentration within the guidance value range for Category 2 in the inhalation exposure test on rats and mice (NICNAS (2003)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour TLm=0.2mg/L of fishes (Bluegill) (NICNAS, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.7(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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