GHS Classification Result

Chemical Name:Methyl isobutyl ketone
CAS:108-10-1

Result:
ID: 974
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: <23degC, Boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 460degC (ICSC (J) (1990)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 value=2080mg/kg (CERI Hazard Data (2000), EHC 117(1990), ACGIH (7th, 2001), DFGOT vol.13 (1999), PATTY (4th 1994)), 4600mg/kg (CERI Hazard Data (2000), EHC 117(1990), DFGOT vol.13 (1999)), 4570mg/kg (EHC 117(1990)), 4500mg/kg (ACGIH (7th, 2001)), 4540mg/kg (PATTY (4th 1994)) and 3200mg/kg (PATTY (4th 1994)). Calculated based on the data above. Since the calculated values was 2919mg/kg, it was classified to category 5.
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rabbit LD50 value = 3000mg/kg (CERI Hazard Data (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Lower value was adopted based on rat LC50 (4 hours) = 8.2mg/L and 16.4mg/L (CERI Hazard Data (2000), EHC 117 (1990), DFGOT vol.13 (1999)). Moreover, it was classified by the ppm concentration standard, because the steam with almost free of mist from vapor pressurethe. The converted value is 2000ppm from the conversion coefficient, and it was classified as Category 3.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - There is description that mild or very mild stimulant under a test condition severer than the OECD Guidelines was acknowledged by the test using rabbits and guinea pigs (CERI Hazard Data (2000), EHC 117 (1990), DFGOT vol.13 (1999), and PATTY (4th 1994)). But it was estimated that there is no stimulant even under a test condition severer than the OECD Guidelines in general (6 time as many valid time as this, blockade application) by the joint controlled trial using a rabbit by 23 research-institute (PATTY (4th 1994)). So it was set as the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - Although we found the descriptions that irritant property was seen in human vapor exposure examples (CERI Hazard Data (2000), EHC 117 (1990), ACGIH (7th, 2001), and PATTY (4th 1994)), we found no case reports about the case where liquid droplets entered into the eyes. On the other hand, by the Draize tests using the rabbits in ECETOC TR 48 (1992), change of the eye which suited the criteria for diagnosis of irritation was not acknowledged, and the change recovered within seven days, in addition, in the 24-instituites-joint multicenter comparison trial by the unification standard examining method using the rabbit in PATTY (4th 1994), it was estimated that it had no irritant property in 75% (18 institutes). Therefore we classified it as out of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the description that sensitizing property was not acknowledged by Magnusson-Kligman maximization test (test according to OECD guideline 406) using the guinea pigs in DFGOT vol.13 (1999), we classified it as Out Of Category.
5 Germ cell mutagenicity Not classified - - - - There is a negative result (CERI Hazard Data (2000), EHC 117 (1990), IRIS (2003)) by the micronucleus test which uses the mammalian erythrocyte, which is the in vivo mutagenicity test using a somatic. So it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into I (inadequate for an assessment of human carcinogenic potential) in EPA (2005), it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as Category 2 based on the description that effect was not observed in fecundity and next growth in the two-generation reproduction study of DFGOT vol.13 (1999), and the description that weight loss and ossification delays were seen but teratogenesis is observed in the fetal at the dose of the dam in toxicity of the inhalation toxicity study using pregnant rat either in CERI Hazard Data (2000), EHC 117 (1990), ACGIH (7th, 2001), DFGOT vol.13 (1999), PATTY (4th 1994), and IRIS (2003) and since reproductive toxicity in the example of human exposure was not reported.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Because of descriptions in CERI Hazard Data (2000), EHC 117 (1990), ACGIH (7th, 2001), DFGOT vol.13 (1999), PATTY (4th 1994) and IRIS (2003) referring to confirmation of central nervous system manifestations accompanied by respiratory tract and mucosa stimulativeness and by anesthetic actions, such as headache, giddiness, nausea, etc. in human exposure cases, and of descriptions in EHC 117 (1990), PATTY (4th 1994),DFGOT vol.13 (1999) and IRIS (2003) referring to that anesthetic actions were confirmed in animal experiments. So it was considered that there were respiratory irritation and anesthetic actions, and determined to be Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (systemic toxicity) Danger H372: Cause damage to organs through prolonged or repeated exposure (systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the descriptions that various symptoms that target internal organs cannot be specified, such as, weakness, headache, burning sensation in eyes, stomachache, nausea and vomiting, and pharyngeal pain in repetitive exposure to humans (the industrial hygiene society advice (1993) p237, EHC 117 (1990), DFGOT vol.13 (1999) and CERI Hazard Data (2000)), it was judged to have systemic toxicity and was classified into Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 2 because of being a primary normal alcohol composed of carbon atoms (3<=n>=13) and containing an isobutyl alcohol and ketone composed of carbon atoms (n>=13).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50=170mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2000).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=19000mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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