GHS Classification Result

Chemical Name：m-Phenylene-bis(methylamine)
CAS：1477-55-0

Result：
ID: 966
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although it is classified into the class 8 in UNRTDG, identification with skin caustics cannot be performed.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on the following data: Rat LD50 value: 930mg/kg (ACGIH 7th, 2001), 660mg/kg (ACGIH 7th, 2001) and 980mg/kg (SIDS, 2001). Since the calculated values was 693mg/kg, it was classified to category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on rabbit LD50 value: 2000mg/kg (ACGIH 7th, 2001).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (1 hour) value: 3.75mg/L (4-hour equivalent 0.938mg/L) (ACGIH 7th, 2001) and LC50 (4 hours) value: 0.8mg/L (SIDS, 2001), it was set as Category 3.
2 Skin corrosion/irritation Category 1B Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description that caustic is in the skin of the guinea pig by apply of a stock solutions (ACGIH (7th, 2001)), and description that internal bleedings were acknowledged in 3 minutes, the necrosis was acknowledged 5 minutes afterward, and the erythema of the skin, dropsy, bleeding, and a necrosis were acknowledged in the all examples of six animals 60 minutes afterward by apply on the rat skin (SIDS (2001)), and bleeding and a necrosis were acknowledged within 60 minutes by skin apply to a mouse, it was judged that there was caustic, and it was set as Category 1B.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since we found the data which stated that it had skin corrosivenesses in the test using the rat (SIDS (2001)), we classified it as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		We categorized it as Category 1 based on the description that positive rates of sensitizing property was 70% in maximization test using the guinea pigs in SIDS (2001).
5 Germ cell mutagenicity Not classified - - - - There is a negative result (SIDS, 2001, ACGIH 7th, 2001) by the micronucleus test which used the mouse erythrocyte ,which is an in vivo mutagenicity test using a somatic. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that reproductive toxicity was not observed at the dose in which general toxicity is observed in parental animals in the oral administration simple reproductive toxicity studies using the rat (the Health, Labor and Welfare Ministry reports (2005), SIDS (2001)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was judged as Category 1 (respiratory tracts) because of descriptions in ACGIH (7th, 2001) and SIDS (2001) referring to that effects on respiratory systems were confirmed at concentration within the limits of guidance value of Category 1 through a inhalation exposure test using rats.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Based on descriptions that no significant toxic effect, except for the disorder against the gastric mucous membrane, was observed with dose exceeding the guidance value range for Category 2 in the oral administration study on rats (the Health, Labor and Welfare Ministry reports (2005) and SIDS (2001)), it was classified as out of Category. Since there was skin corrosivity, the effect of oral administration on the digestive system was judged to be local effects, and they were not taken as target organ.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72-hour ErC50=14mg/L of algae (Scenedesmus) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 22% (existing chemical safety inspections data)), though less bio-accumulative (BCF<2.7 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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