GHS Classification Result

Chemical Name：Acetic anhydride
CAS：108-24-7

Result：
ID: 965
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 316degC (ICSC (J), 1993)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is also information that it is classified into the UNRTDG class 8 and it corrodes many metals (ICSC (J) (1993)), there is no data based on set test methods.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value: 630mg/kg (CERI Hazard Data, 2001, DFGOT vol.13, 1999), and 1780mg/kg (CERI Hazard Data, 2001, DFGOT vol.13, 1999, SIDS, 1997). Based on the above data, it was classified as category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rabbit LD50 value: 4000mg/kg (CERI Hazard Data, 2001, DFGOT vol.13, 1999, SIDS, 1997), and 4321mg/kg (CERI Hazard Data, 2001).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Lower value was adopted from rat LC50 (4 hours) value: 1000ppm (equivalent: 4.167mg/L) (CERI Hazard Data 2001, SIDS, 1997) and 2000ppm (equivalent 8.334mg/L) (CERI Hazard Data, 2001). 1000ppm was considered as the steam with almost no mist from vapor pressure. And classified as Category 3 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is description that mild to moderate skin stimulativeness was acknowledged in the test which was used the rabbit (CERI Hazard Data (2001), DFGOT (vol.13, 1999), and SIDS (1997)). But from description that serious burn and blister formation are reported in the skin of the humans (CERI Hazard Data (2001) and SIDS (1997)), it was judged that it was caustic, and it was set as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is the description that severe irritant property was acknowledged in the tests applied to the eyes of the rabbits (CERI Hazard Data (2001), DFGOT (vol.13, 1999) and SIDS (1997)), and on the description that the drug-induced severe burn injury on the cornea, loss of eyesight, etc. were reported in the occupational exposure examples (CERI Hazard Data (2001), DFGOT (vol.13, 1999), SIDS (1997) and Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1990)). So we judged it had causticity and classified it as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - There is a negative result (SIDS, 1997) by the micronucleus test which used the rat erythrocyte, which is the in vivo mutagenicity tests using a somatic. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - There is a description that in an inhalation exposure test using pregnant rats in SIDS (1997) whole embryos absorption was observed in two of four at the concentration in which general toxicity is observed in parental animals. Therefore, it may be classified into Category 2. However, there are only four pregnancy animals in each group, and the data is insufficient. Therefore, since the data is insufficient, it cannot be classified.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was judged as Category 1 (respiratory tracts) because of a description in accidental exposure cases of CERI Hazard Data (2001) referring to confirmation of pulmonary edemas, and of descriptions in DFGOT (13 vol. 1999) and SIDS (1997) referring to that airways can be stimulated seriously and sores of nasal mucosas and bronchospasm may be caused. Moreover, it was judged as Category 3 (anesthetic actions) because of a description in SIDS (1997) referring to confirmation of central nervous system depressions at high concentrations as an effect on humans.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified into Category 1 (respiratory tracts) from description that the effects on the respiratory system was observed with the concentration within the guidance value range for Category 1 in 13-week inhalation exposure test on rats (SIDS (1997)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24-hour LC50=55mg/L of Crustacea(Daphnia magna), and others (SIDS, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (it hydrolyzed and acetic acid (BOD: 74% (Existing Chemicals Safety Check Data)) is generated, and supposed less bio-accumulative (log Kow=-0.58 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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