GHS Classification Result

Chemical Name：Formamide
CAS：75-12-7

Result：
ID: 961
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: >500degC (Ullmanns (E), 5th, 1995, A12: p.1-3)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes copper etc. (HSDB (2005)), there is no data based on set test methods.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Not classified because of SPECIES: Rat; ENDPOINT: LD50; VALUE: : approximately 6000mg/kg; REFERENCE SOURCE: ACGIH 7th, 2001)
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value: 6000mg/kg (ACGIH 7th, 2001), and outline fatal dose: 17000mg/kg (ACGIH 7th, 2001), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - From description that a toxic phenomena was not acknowledged in 3900ppm of 6-hour exposure (4-hour equivalent 10.75mg/L) in the inhalation exposure test of the mist using the rat (ACGIH (7th, 2001)), it was set as the outside of Category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that slight transient skin irritations was admitted in the test using the guinea-pig (ACGIH (7th, 2001)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		We classified it as Category 2B based on the description that the very slight transient stimulant action was acknowledged in the test applied to the eyes of the rabbits (ACGIH (7th, 2001)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although we found the description that skin sensitizing property was not acknowledged in the test using the guinea pigs in ACGIH (7th, 2001), we presupposed that we could not classify it since the test method is unknown and sufficient data to classify it as Out Of Category was not obtained.
5 Germ cell mutagenicity Not classified - - - - There was a negative result by the micronucleus test which used the mouse red corpuscles, which are the in vivo mutagenicity tests using a somatic (NTP DB, 2005). So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - In the oral administration study using pregnancy rats and rabbits in the NTP DB (2005), there is a description that specific reproductive toxicity was not observed at the dose in which general toxicity is observed in parental animals. Therefore, it was out of the Category. Moreover, there is no descriptions on general toxicity of parent animals in the ACGIH (7th, 2001). However, there is a description that reproductive toxicity was not observed in the percutaneous administration examination using pregnant mice and rats. Specific reproductive toxicity was not also observed in the oral administration fertility study using the male and female mice in NTP DB (2005).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There was a description in ACGIH (7th, 2001) referring to that toxic phenomena were not confirmed at high concentrations beyond the guidance value limits of Category 2 in mist inhalation exposure tests using rats, while there is no other data, and determined that it cannot be classified as out of Category because of lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there was description that toxic effect was not observed with the dosage within the guidance value range for Category 2 in 90 day dermal administration test on rats (ACGIH (7th, 2001)), since there was no other data which clearly deny hazard with Priority 1, it was presupposed that data is insufficient and it cannot classified as out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100 mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1998).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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