Chemical Name:heptachlor epoxide
CAS:1024-57-3
ID: | 945 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | No data available |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements). |
15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :34mg/kg (used to classify) and 62 mg/kg; REFERENCE SOURCE: JMPR (1965, 1966) | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Although the negative result is obtained by the dominant lethal test using a mouse (JMPR 1991; IRIS 2006; ATSDR 2005), there was no in vivo mutagenicity test data using germ cells and somatics. So it carried out the outside of Category. |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since it was classified into 2B (IARC 79, 2001) in IARC, A3 (ACGIH, 7th, 2001) in ACGIH, B-2 (IRIS and Last revised on 1993) in EPA and was the category 3 (EU-ANNEX I, 2006) in EU, it was considered as Category 2. | |
7 | Reproductive toxicity | Category 1B | Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 1B, since the death of F1child, a macroscopic pathology view or increase of liver weight in the liver of F1 child was seen at the dose in which maternal toxicity is not observed in the two-generation reproduction study using a dog (JMPR (1991, EHC 38, 1984).). | |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Insufficient data available. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In two year oral (feeding) administration test on dogs, the administrated group with dosage observing the guidance value range of Category 1, the increase in weight of liver, the change of the index which suggests a liver damages in blood biopsy inspection (elevation of SGPT actives, etc.), histopathological alterations (enlargement and vacuolation on centrilobular hepatocyte, appearance of detailed granule and ground-glass like cytoplasm) were observed (JMPR 1965, 1966, and 1991, PD 19 1975, EHC 38 1984, ACGIH 7th.2001, IRIS Access on Jan. 2006 and IARC Vol.53(1991) p.115-164), therefore, target organ were judged to be liver and were classified as Category 1 (liver). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96-hour LC50=0.04microg/L of Crustacea (Pink shrimp) (AQUIRE, 2003). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.98 (PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |