GHS Classification Result

Chemical Name：Hexane
CAS：110-54-3

Result：
ID: 941
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <23degC, Initial boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 225degC (ICSC (J), 2000)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Rat Oral LD50 value=25000mg/kg (MOE Risk Assessment vol.1(2002)), 28700mg/kg (EHC 122 (1993), DFGOT vol.14 (2000), PATTY (4th, 1994) , ATSDR (1999)), 32400mg/kg (EHC 122 (1993), DFGOT vol.14 (2000), ATSDR (1999)) and 15800mg/kg (EHC 122 (1993), DFGOT vol.14 (2000), ATSDR (1999)). Based on the above data, calculated value was applied for categorization. LD50 value calculation = 19634mg/kg
1 Acute toxicity （Dermal） Classification not possible - - - - There was the description that death was seen in rabbits at 5 mL/kg (reduced value = 3297mg/kg) at PATTY (4th, 1994). But there was no information on LD50 value, it was not able to be classified since data was insufficient.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Judging it as steam from steam pressure. Calculated based on rat inhalation LC50 (1 hour) = 77000ppm (4 hour equivalent: 38500ppm [135.46mg/L]) (EHC 122 (1993), DFGOT vol.14 (2000)), LC50 (4 hours) = 74000ppm (equivalent: 260.36mg/L) (EHC 122 (1993) and DFGOT vol.14 (2000)) and 48000ppm [equivalent: 168.88mg/L] (MOE Risk Assessment the 1st volume (2002)). But the calculated value was lower than the lowest value among these data, the lowest value (38500ppm [135.46mg/L]) was adopted. And based on this value, it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that skin irritation was seen in humans evidence of exposure (MOE Risk Assessment The 1st volume (2002), EHC 122 (1993), DFGOT vol.14 (2000), PATTY (4th, 1994), ATSDR (1999)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A-2B. Based on the description that the ocular irritant property was acknowledged in human exposure examples (MOE Risk Assessment 1st volume (2002)), and on the description that mild irritant property was acknowledged in the rabbits (DFGOT vol.14 (2000)). The level of irritation and resilience are unknown, therefore deliberate categorization was impossible.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although we have descriptions in which it is supposed that sensitizing was not acknowledged in EHC 122 (1993) and DFGOT vol.4 (1992) by Maximization test for 25 humans, we presupposed that we could not classify it since this report singularly is inadequate for considering it as a clear proof of there being no sensitizing property.
5 Germ cell mutagenicity Not classified - - - - There is negative result by the dominant lethal test using rodents (EHC 122 (1993), DFGOT vol.4 (1992), ATSDR (1999)), and by the micronucleus test using mammalian erythrocyte(ATSDR (1999)), and by the chromosomal aberration test using mammals marrow cells (DFGOT vol.4 (1992)), it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - Since it is not evaluated in the institution indicated in the technical indicator, it cannot be classified.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as category 2 since there is description that the organization injury of the testis accompanied by inhibition of spermatogenesis is observed by inhalation exposure to a rat (EHC 122 (1993), DFGOT vol.4 (1992), IRIS (Access on July 2005) and ATSDR (1999)), and in 1000ppm exposure effect is observed in a testis, muscular atrophy (DFGOT vol.4 (1992)) and weight loss (ATSDR (1999)) were also shown.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is descriptions in EHC 122 (1993), ACGIH (7th, 2001), DFGOT vol.4 (1992), and PATTY (4th, 1994) referring to confirmation of giddiness, central nervous system depressant, etc. as acute inhalation toxicity in humans, it was judged that these effects were caused by anesthetic actions. Moreover, it was judged as Category 3 because of descriptions in ACGIH (7th, 2001) and PATTY (4th, 1994) referring to confirmation of respiratory irritant caused by inhalation exposure to humans, and of a description in PATTY (4th, 1994) referring to confirmation of anesthetic actions.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, peripheral nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, peripheral nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that polyneuropathy (disorder of sensory nerve and motor nerves) is observed in human chronic exposure examples (MOE Risk Assessment The 1st volume (2002), EHC 122 (1993), ACGIH (7th, 2001), DFGOT vol.14 (2000), PATTY (4th, 1994), IRIS (2005), Japan Society for Occupational Health advice (1993), and ATSDR (1999)), target organs were judged to be central nervous systems and peripheral nervous systems, and we categorized it as Category 1.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is a hydrocarbon and the dynamic viscosity at 40 degrees C is 20.5mm2/s or less, we classified it as Category 1. There was description of chemical pneumonia by the Aspiration in the rat (DFGOT vol.4 (1992)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour LC50=3.88mg/L of Crustacea (Daphnia magna) (EHC122, 1991).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 100% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=3.9 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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