GHS Classification Result

Chemical Name：hexamethylphosphoric triamide
CAS：680-31-9

Result：
ID: 940
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :2650mg/kg; (male), 3360mg/kg; (female) REFERENCE SOURCE: ACGIH (7th, 2001) and IARC Vol. 15 (1977)
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rabbit LD50 value: 2600mg/kg (ACGIH (7th, 2001) and IARC Vol.15 (1977)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on description that there was severe irritation in the skin irritation test in guinea pigs (RTECS (2005)), and description that it might indicate irritation when the human skin were touched (HSFS (2001)), it was set as Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is positive finding (IARC Vol. 15 (1977), IARC Vol. 71 (1999)) by the dominant lethal test using a mouse (rodent), and the classification in EU ANNEX I (2005) into Category 2; R46. So it is set as Category 1B.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into the category 2 in EU (EU ANNEX I (2005)). But it was classified into 2B in IARC (IARC 71 (1999)) and in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005), A3 in ACGIH (ACGIH (7th, 2001)), and R in NTP (NTP RoC (11th, 2005)). So it was considered as Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the description that in ACGIH (7th, 2001), "testicular atrophy and aspermia happen by oral administration to rat", in IARC Vol.15 (1977), "azoospermia, testes weight loss and gonad cell destruction are observed at the observation period for 23 weeks after 500mg/kg/day carries out repetitive oral administration for six days to rat." In addition, it was considered as category 2 based on the description that as human impact, to HSFS (2001) "a teste (males gonadal) may be destroyed", and the description that "a male teste is damaged and there is limited evidence to which it is supposed that spermatogenesis may be affected" in SITTIG (4th, 2002).
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, kidney, central nervous system) Warning H371: May cause damage to organs (respiratory system, kidney, central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As effects on humans, based on a description that "lungs, kidneys, and central nervous systems are affected and then functional disorder and functional fall may be caused"(ICSC (J) (1994)), and on a description taht "noses and throats may be stimulated by inhalation"(HSFS (2001)), and on a description taht "noses, throats, and lungs are stimulated and damaged and nasal discharges may be caused and lungs can be changed through exposure"(SITTIG (4th, 2002)). So it was judged as Category 2 (respiratory systems, kidneys, central nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		We have the description that the degeneration of the kidney nephric tubule epithelium was observed with 0.4 ppm exposure in the guidance value range of Category 2 in the three-month inhalation exposure test in the rat (ACGIH 7th, 2001), description that respiratory mucosal and lung dysfunction were observed with the dose in the guidance value range of Category 1 in the 6-to-24-month inhalation exposure test for the rat (IARC 71 (1999)), and the description that in the feeding administration tests for 52 to 72 days in the rat, bronchial mucosas damage was observed with just about the dose of the guidance value range of Category 2. Moreover, as the impact on human, there is a description that "respiratory tract, the kidney, and marrow may be affected"(ICSC (J) (1994)), and there's a description that the respiratory system is affected (HSFS (2001)), and there was description that it might effect on the kidney, lungs, and the respiratory tract (STIIG (4th, 2002)), therefore the target organs of this product were judged to be respiratory systems and the kidney, so we classified it as Category 1 and 2, respectively. In addition, for marrow, neither animal data nor the clinical case reports was clear.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 48-hour LC50=6670000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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