GHS Classification Result

Chemical Name：Benzene, hexachloro-
CAS：118-74-1

Result：
ID: 938
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG Class: 6.1
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - UNRTDG Class: 6.1
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 value:3500mg/kg (EHC 195 (1997), ACGIH 7th (200)1, DFGOT vol.16 (2001), PATTY 4th (1994), IARC 79 (200), ATSDR (2002)) and 10000mg/kg (MOE Risk Assessment vol.1(2002), EHC 195 (1997), ACGIH 7th (2001), IARC 79 (2001)). Based on the values above, the lower value was adapted. And it was classified to category 5.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - There is description that the skin irritation of laboratory animals is low (EHC 195 (1997), DFGOT (vol.16, 2001)). But an animal species, valid time, etc. were unknown, it could not be classified since data was insufficient.
3 Serious eye damage/eye irritation Not classified - - - - We classified it as out of Category based on the descriptions that it had no ocular irritant property in the laboratory animals although the species of the animals tested was unknown(EHC 195 (1997), DFGOT (vol.16, 2001)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Since data was insufficient, we could not classify it.
5 Germ cell mutagenicity Not classified - - - - There is a negative result in the dominant lethal test using the rat, which is an in vivo multigeneration mutagenicity test using a germ cell (IRIS, 2005, ATSDR, 2002, EHC 195, 1997, ACGIH 7th, 2001, DFGOT vol.16, 2001, PATTY 4th, 1994, IARC 79, 2001). So it carried out outside Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into the category 2 (EU-ANNEX I, 2005) in EU. But it was classified into group 2B (IARC 79, 2001) in IARC, A3 (ACGIH 7th, 2001) in ACGIH, B-2 (IRIS, 2005) in EPA in 1996, and R (NTP RoC 11th, 2005) in NTP. So it was considered as Category 2.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1A based on expert judgement since there is a description that description that significant increase mortality after birth of a child animal was observed in the oral administration examination during pregnancy and the oral administration reproductive examination using the rat or mouse (MOE Risk Assessment the 1st volume (2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT (vol.16, 2001), PATTY (4th, 1994) and IARC 79 (2001)), and the description that the newborn who drank the breast milk has died by humans exposure (IARC 79 (2001), EHC 195 (1997)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, skin, thyroid, bone, kidney, endocrine system), Category 2 (immune system, nervous system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, skin, thyroid, bone, kidney, endocrine system)
H373: May cause damage to organs through prolonged or repeated exposure (immune system, nervous system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in accidental exposure example by the oral ingestion to the human, the influence on liver, the skin, a bone, or the thyroid, such as the liver dysfunction, cutaneous porphyrias, arthritis, and a hypertrophied thyroid was observed (MOE Risk Assessment The 1st volume (2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT (vol.16, 2001), PATTY (4th, 1994), and IARC 79 (2001)), and the description that the effects on the kidney and adrenal gland was observed with the dose of the guidance value range of Category 1 in the oral study using the rat (IRIS (2005), ATSDR (2002), DFGOT (vol.16, 2001), and EHC 195 (1997)), and based on the description that the influence to the nervous system, such as a tremor, and immune suppression were observed in the range of guidance value of Category 2 in the oral study using the rat or mouse (ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), IARC 79 (2001), PATTY (4th, 1994)), it was categorized as Category 1 (liver, the skin, the thyroid, the bone, the kidney, an endocrine systems), and Category 2 (immune systems, nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 24-hour EC50<30microg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=30000 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information