GHS Classification Result

Chemical Name:halothane
CAS:151-67-7

Result:
ID: 932
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (ICSC(J), 2005; etc.).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC (J), 1995; etc.)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(J), 1995; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 5680 mg/kg REFERENCE SOURCE: RTECS (2005)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Based on rat LC50 (4 hour exposure with vapor): 120000mg/m3 ( = 120mg/L), it was classified as out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Severe irritant property was acknowledged by the ocular irritation tests with the rabbits (RTECS (2005)). However, it was unstated about irreversible lesions, therefore we classified it as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it was classified into a group 3 in IARC (1987) and A4 in ACGIH (2001), it was considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (cardiovascular system, liver), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (cardiovascular system, liver)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Because of descriptions in ACGIH (7th, 2001) referring to that depression in central nervous systems were clear as acute toxicity in humans, and of a description referring to anesthetic actions classified in Category 3 and descriptions indicating amnesia, paralysis to pain sensation, and respiratory depression, and of descriptions indicating control of cardiovascular systems, arrhythmia, blood vessel extension, and liver lesions (hepatitis, necrosis). So it was judged as Category 1 (cardiovascular systems, liver) and Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is description that the change was observed in the ultrastructure of the nerve cell in 4 or 8-week inhalation exposure test in the rat (IARC (1975) and ACGIH (7th, 2001)), it was not considered to be the impact which indicates the classification since the kind and the part of nerve cell, and effects on nervous function and a toxicological meaning were unknown, therefore we presupposed that we could not classify it because of the lack of data.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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