GHS Classification Result

Chemical Name:2-Propanol
CAS:67-63-0

Result:
ID: 928
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: <23degC, Initial boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 399degC (NFPA, 12th, 1997, p325-81, 325-63)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 = 5280mg/kg (EHC(1990), SIDS(1997)), 5500mg/kg (EHC(1990), SIDS(1997), CERI Hazard Data (1999)), 5480mg/kg (EHC(1990), PATTY(1994)), 4710mg/kg (EHC(1990), PATTY(1994), SIDS(1997)) and 1870mg/kg (CERI Hazard Data (1999)).The statisticallly calculated toxicity value was 3437mg/kg, and it was classified to category 5.
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. There are rabbit LD50 = 12870mg/kg (EHC (1990), PATTY (1994), SIDS (1997), CERI Hazard Data (1999)), and 4059mg/kg (CERI Hazard Data (1999)), and it was set as Category 5 from the lower value.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Based on rat LC50 (4-hour exposure to vapor) = 72600mg/m3 (29512ppm)(EHC (1990), PATTY (1994), SIDS (1997)), and 29620ppm (72,865mg/m3) (CERI Hazard Data (1999)), it was over the range of Category 5 of the ppm concentration standard value with exposure in the steam with no mist. So it was considered as the out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - There is a report of no irritation or of mild irritation in the tests for rabbit skin irritation (EHC 103 (1990), PATTY (4th, 1994), ECETOC TR66 (1995), and CERI Hazard Data (1999)). But from the report that irritation was not indicated in the test which was done skin application for the medical treatment of the volunteer and an alcoholism patient in the humans (EHC 103 (1990)), it was set as the outside of Category .
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
We found the descriptions that there were reports of slight to severe ocular irritatant property in the eye irritation tests with the rabbits (EHC (1990), SIDS (1997), PATTY (1994), ECETO TR (1992), and CERI Hazard Data (1999)). However, critical damaging property was not indicated, therefore we classified it as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - It was negative for skin sensitization test by the Buehler method in the guinea pig in SIDS (1997). On the other hand, dermatitis development examples of EHC (1990) who indicated the positive reaction to patch test with 2-propanol also indicated positive reaction to low molecular first class or second class alcohols, and propylene oxide. Since 2-propanol was not clear whether it is an causative agent, we presupposed that we could not classify it for the lack of data.
5 Germ cell mutagenicity Not classified - - - - Since it is negative in the micronucleus test which used the mouse bone marrow cells by in vivo of SIDS (1997), it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into a group 3 in IARC (Access on Oct 2005) and A4 in ACGIH (2003), it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the two-generation reproduction study by the drinking water medication using rats (EHC (19990), IARC (2005), and PATTY (1994)), there was no influence on fertility and growth of born children. On the other hand, no teratogenicity was observed in rats in the growth toxicity and the teratogenicity test in EHC (1990), SIDS (1997) and ACGIH (2003). However, reproductive toxicity, such as decline in a pregnancy rate, an increase in embryo absorption, and an increase in fetus death, were observed at the dose in which a fall of the increaseing weight, and toxicity such as an anesthesia action to parental animals were observed. Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, kidney, systemic toxicity), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system, kidney, systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
PATTY (1994) and ACGIH (2003) have descriptions that there is an active decrease caused by inhalation exposure using rats, while ACGIH (2003) and CERI Hazard Data (1999) have descriptions that stimuli to alimentary canals, decreases of blood pressure and temperature, etc., central-nerves condition; and kidney damage have been confirmed through acute poisoning to humans caused by oral ingestion. Target organs were judged as central nervous systems, kidney and systemic toxicity, and determined to be Category 1. Moreover, irritation to noses and throats in humans is confirmed in ACGIH (2003). It was judged that there was respiratory irritant, and determined to be Category 3.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood vessels, liver, spleen) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood vessels, liver, spleen) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description that effect on a blood vessel, liver, and a spleen were observed in 86 days or a four-month inhalation exposure test in the rat (EHC (1990)), we considerd target organs as blood vessel, liver and spleen and classified into Category 2. In addition, in the dose exceeding the guidance value of Category 2, renal effects and anesthetic actions are observed.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although we have no information for human, the death of cardiopulmonary arrest is observed within 24 hours by the intratracheal administration in the rat (EHC (1990) and PATTY (1994)). And the dynamic viscosity was around 1.6 approximately, we judged that there was aspiration breathing apparatus hazards, and we classified it as Category 2.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1997).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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