GHS Classification Result

Chemical Name：2-Furanmethanol
CAS：98-00-0

Result：
ID: 925
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 391degC (Ullmanns (E) (5th, 1995) A12: p119-120)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on the following values: Rat LD50 value: 110mg/kg (DFGOT vol.7, 1996), 132mg/kg (DFGOT vol.7, 1996, PATTY 4th, 1994), 275mg/kg (DFGOT vol.7, 1996, PATTY 4th, 1994) and 451mg/kg (DFGOT vol.7, 1996). Since the calculated values was 141mg/kg, it was classified to category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rabbit LD50 value: 657mg/kg (DFGOT vol.7, 1996, PATTY 4th, 1994).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (4 hours) value: 233ppm (equivalent: 0.933mg/L) (ACGIH 7 th, 2001, DFGOT vol. 7, 1996, and PATTY 4 th, 1994), the vapor pressure of 233ppm indicates steam with almost no mist. And it was classified as Category 2 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that irritation was admitted in the test using the rabbit (IUCLID (2000)) and description that the skin was stimulated (ICSC (J) (1997), HSFS (1998)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A based on the descriptions that reversible inflammation and corneal opacity were acknowledged in the test applied to the eyes of the rabbits (DFGOT (7 vol. 1996) and PATTY (4th, 1994)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although we found the description that the symptom of cutaneous sensitization was acknowledged in PATTY (4th, 1994) with the guinea pigs, the testing methods were unknown, therefore we presupposed we could not classify because of the insufficiency of data.
5 Germ cell mutagenicity Not classified - - - - There is a negative result (NTP TR 482, 1999) in the chromosomal aberration test with the mouse marrow cells, which are the in vivo mutagenicity tests with a somatic, and in the micronucleus test with mouse erythrocyte. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of descriptions in ACGIH (7th, 2001) and Japan Society for Occupational Health recommendation (1993) referring to confirmation of drowsiness through inhalation exposure test using rats, and of description in ACGIH (7th, 2001) referring to that respiratory tracts are stimulated as an effect on humans, it was judged as Category 3 (anesthesia action, respiratory irritation)
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (liver, kidney, central nervous system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, central nervous system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		We classified it as Category 1 (respiratory systems) and Category 2 (liver, kidney, central nervous system), based on the descriptions that the effects on the respiratory system were observed with the concentration of the guidance value range of Category 1 in the repeated inhalation exposure test using rat and mouse (ACGIH (7th, 2001), NTP TR 482 (1999), and PATTY (4th, 1994)), based on the description that the effects on the kidney and the liver were observed with the dosage of the guidance value range of Category 2 in the 13-week oral study using rat (NTP TR 482 (1999)), and also based on the descriptions that the effect to brain was observed with the concentration of the guidance value range of Category 2 in the inhalation exposure test using rat (ACGIH (7th, 2001), DFGOT (vol.7, 1996), and NTP TR 482 (1999)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=32mg/L of fishes (Fathead minnows) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 78% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.28 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information