GHS Classification Result

Chemical Name：2-Propanol, 2-methyl-
CAS：75-65-0

Result：
ID: 915
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although there are information, flash point, flame range, etc., which indicate it is a flammable liquid (ICSC (J) (1995) and others) there is no data with these test methods.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 470degC (ICSC (J), 1995)
11 Self-heating substances and mixtures Classification not possible - - - - Test suitable for a liquid state substance (melting points: 25 degC) has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was classified to category 5 based on the following values. Rat LD50 value: 2200mg/kg (DFGOT vol.19 (2003)) and 3500mg/kg (CERI Hazard Data (1997), ACGIH 7th (2001), DFGOT vol.19 (2003), PATTY 4th (1994), NTP TR53(1997), EHC 65 (1987) and Advice of Sanei Academy (1993)).
1 Acute toxicity （Dermal） Not classified - - - - From the description that death was not observed at 2000mg/kg in the test using rabbits (DFGOT (vol.19, 2003)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There is description that 1 of 10 rats died from 4 hour exposure to 7060 ppm (equivalent 21.36mg/L) (DFGOT (vol.19, 2003)). But the existence of the death with LC50 value and with the upper limit of Category 4 is unknown. Since data is insufficient, it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is description that skin irritation was not admitted by the test which used the rabbit (DFGOT (vol.19, 2003)). But it was set as Category 3 from description that there was slight skin irritation by the humans (CERI Hazard Data (1997), DFGOT (vol.19, 2003), PATTY (4th, 1994), NTP TR53 (1997), Occupational Health Recommendation of Occupational Exposure Limits (1993), ACGIH (7th, 2001), and EHC 65 (1987)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A-2B based on the description that by application to eye, the moderate irritation was acknowledged in the test using the rabbits (DFGOT (vol.19, 2003)), and on the description that it stimulated the human eye (CERI Hazard Data, PATTY (4th, 1994), and ACGIH (7th, 2001)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - About cutaneous allergic response, there is only one case report (NTP TR53, 1997, ACGIH 7th, 2001 and EHC 65, 1987; they refer the same document) and DFGOT (vol.19, 2003) had description of the two tests which was negative for the first test and weakly positive for the second one using the guinea pigs, therefore we presupposed that we could not classify it for the insufficiency of data.
5 Germ cell mutagenicity Not classified - - - - There is a negative result (CERI Hazard Data, 1997, DFGOT vol. 19, 2003, and NTP TR53 and 1997) by the micronucleus test which used the mouse and rat erythrocyte, which are an in vivo mutagenicity test using a somatic. So it considered as the outside of Category.
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As a result of the examination using a mouse, there is a description in CERI hazard data collection (1997), DFGOT (vol.19, 2003), PATTY (4th, 1994), ACGIH (7th, 2001), NTP (TR53, 1997, TR436, 1995) and EHC 65 (1987) that the decrease in newborn and the increase in stillbirth were observed at the dose in which general toxicity is seen in parental animals. Or, although the general toxicity in parental animals is unknown, there is a description that increase in embryo absorption was observed. Therefore, it was classified into Category 2. In addition, the reproduction toxicity is not clearly observed in parent animals by the dose in which general toxicity was seen in oral administration and an inhalation exposure examination using pregnant rats shown in the CERI hazard data collection (1997), DFGOT (19 vol. 2003), PATTY (4th, 1994), ACGIH (7th, 2001), and NTP (TR 53, 1997 and TR 436, 1995). However, the above developmental toxicity cannot be denied for this result.
8 Specific target organ toxicity - Single exposure Category 2 (liver), Category 3 (respiratory tract irritation, narcotic effects) Warning H371: May cause damage to organs (liver)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		From description in ACGIH (7th, 2001), NTP TR53 (1997), and EHC 65 (1987) that affects on liver function were seen with the given dose of the guidance value range of Category 2 in the single-dose oral study using rats, it was set as Category 2 (liver). Moreover, from description in DFGOT (vol.19, 2003), PATTY (4th, 1994), and ACGIH (7th, 2001) that the anesthetic actions were seen in the inhalation exposure test using rats and in the oral study using rabbits, description in CERI Hazard Data (1997) that as affect on humans, headache, muscular asthenia, giddiness, ataxia, and distraction are caused, and description in PATTY (4th, 1994), and DFGOT (vol.19, 2003) that nose and throat are stimulated as affect on humans. So it was set as Category 3 (anesthetic actions, respiratory stimulatory).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - We categorized it to be Out Of Category because significant toxicity was not observed with the dose of the guidance value range of Category 2 in the repetitive oral administration test and inhalation exposure test using the rat and mouse (CERI Hazard Data (1997), DFGOT (vol.19, 2003), PATTY (4th, 1994), and NTP TR436 (1995)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 48-hour EC50=5504mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 1997).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
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Model SDS by MHLW

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