GHS Classification Result

Chemical Name：1-Propanol, 2-methyl-
CAS：78-83-1

Result：
ID: 914
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 415degC (ICSC (J), 1995)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat oral LD50 value : 3350mg/kg, 2650mg/kg and 2740 mg/kg (SIDS (2004)), 3100mg/kg ( SIDS (2004), EHC 65 (1987), PATTY (4th, 1994)) and 2460mg/kg (SIDS (2004), EHC 65 (1987), PATTY (4th, 1994), Recommendation of Sanei Academy(1993)). Calculated based on the values above. Since the calculated values was 2596mg/kg, it was classified to category 5.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rabbit LD50 value: 2460mg/kg (SIDS (2004)), 4240mg/kg (SIDS (2004), EHC 65 (1987)), and 3400mg/kg (SIDS (2004), PATTY (4th, 1994)). Since the calculated values was 2523mg/kg, it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Lower value was adopted from rat LC50 (4 hours): 19.2mg/L (SIDS (2004) and EHC 65 (1987)) and 24.2mg/L (Industrial Hygiene Society advice (1993)). 19.2mg/L (equivalent: 6336ppm) considerd to steam with almost no mist from the vapor pressure. And it was classified as Category 5 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From description that mild redness was seen by applying on the human skin (ACGIH (7th, 2001), PATTY (4th, 1994), and Occupational Health Recommendation of Occupational Exposure Limits (1993)), and from description that skin changes were not restored within seven days by the Draize tests (OECD Guidelines 404 conformity good laboratory practice tests) using the rabbit (SIDS (2004)), it was set as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There was no case in which the liquid was applied to human. But there is the descriptions that ocular irritant property and the change of cornea was seen in the human cases of steam exposure (PATTY (4th, 1994), DFGOT vol.19 (2003), Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993)), and on the description that in the Draize test (OECD Guidelines 405-compliant good laboratory practice study) using the rabbit, slight conjunctival reddening was acknowledged even 21 days after (SIDS (2004)), and on the result in which was applicable to the judging standard, that it had the irritant property by the Draize study using the rabbits (ECETOC TR48 (1992)). So we classified it as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - There is a negative result (SIDS (2004)) by the micronucleus test with the mammalian erythrocyte which is an in vivo mutagenicity test using a somatic, and there is a negative result (SIDS (2004), DFGOT vol.19 (2003)) by the chromosomal aberration test using mammalian bone marrow cell. So it carried out the outside of Category.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that effect was not observed in fetus in the exposure tests to the pregnancy rat and rabbit (SIDS (2004), DFGOT vol.19 (2003), and PATTY (4th, 1994)), and the description that the effect on reproduction toxicity or born child was not seen in the two-generation reproductive study using rat of SIDS (2004). There is no report of the example of human exposure which suggests reproductive toxicity.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in EHC 65 (1987), PATTY (4th, 1994), and Society for Occupational Health Recommendation of Occupational Exposure (1993) that the stimulus of the pharynx was observed in human exposure, it was thought that there was respiratory irritant. Moreover, description in SIDS (2004) that the active fall and the reaction fall of startle reflex were seen in the neurotoxicity study using rats exposed to 3000ppm for 6 hours, and inhibition of the central nervous system was seen in the inhalation exposure test exposed to 15.7mg/L for 4 hours using rats and rabbits of of EHC 65 (1987). So all were reversible transient influences, and it was thought that there was an anesthetic actions. It was set as Category 3 (respiratory irritant, anesthetic actions)
9 Specific target organ toxicity - Repeated exposure Not classified - - - - We categorized it to be Out Of Category because the toxicity which endorses the classification was not observed with the dose which exceeds the guidance value of Category 2, and we had no clear toxic report in the human exposure cases in the 90-day inhalation exposure test (exposure concentrations: 0, 250, 1000 or 2500 ppm)(SIDS (2004), DFGOT vol.29 (2003)), in the 90-day forcible oral administration test (dose: 0, 100, 316 or 1000mg/kg/day) using the rat (SIDS (2004), IRIS (Access on Aug 2005) ) and in the administration test in drinking water for 90 days using the rat (presumed dose: 0, 80, 340 or 1450mg/kg/day) (SIDS (2004), DFGOT vol.19 (2003) and PATTY (4th, 1994)).
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of an isobutyl alcohol (UN Report)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 24-hour EC50=1250mg/L of Crustacea (Daphnia magna) (EHC65, 1987).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility = 85000mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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