GHS Classification Result

Chemical Name：Butan-2-ol
CAS：78-92-2

Result：
ID: 913
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 390degC (Hommel, 1991 Card No.54)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50 value =6500mg/kg (EHC 65 (1987)) ACGIH (2002), DFGOT vol.19 (2003), Based on PATTY (4th, 1994), Recommendation of Sanei Academy(1993), and 2200mg/kg (DFGOT vol.19 (2003)). Based on the data above, the lower value was applied to be classified to category 5.
1 Acute toxicity （Dermal） Not classified - - - - From the description that death was not observed at 2000mg/kg in the dermal administration test using rabbits (DFGOT vol.19 (2003)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Since it was described that there was no skin irritation in the test using the rabbit, and there was no report that indicated skin irritation in the example of human exposure (EHC 65 (1987), ACGIH (2002), DFGOT vol.19 (2003), and PATTY (4th, 1994)), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A based on the description that the disorder was acknowledged in the conjunctiva, iris and cornea by the rabbit study and the symptoms did not recover in one animal on the Day 7 (DFGOT vol.19 (2003)). In addition, we found the description that it had an irritant property on the human eye by exposure to concentrated vapors (PATTY (4th, 1994), Japan Society for Occupational Health Recommendation of Occupational Exposure Limits(1993)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - We found a description that sensitizing property was not acknowledged in Maximization test with the guinea pigs in DFGOT vol.19 (2003). On the other hand, we found a description that there were a few case reports in which skin sensitization was acknowledged in human in PATTY (4th, 1994), however, we found the descriptions in ACGIH (2002) and DFGOT vol.19 (2003) that the examples which gave positive result to 2-butanol by the skin patch tests showed sensitization to primary or secondary alcohols, and it is suggested to be positive reaction by cross sensitization, therefore we could not conclude that 2-butanol itself has a skin sensitizing property. We could not classify it.
5 Germ cell mutagenicity Classification not possible - - - - There are no mutagenicity and genotoxicity study data in the in vivo, and all were negative in the in vitro mutagenicity test. So it cannot be classified.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the two-generation reproduction study by the drinking water medication in rat of ACGIH (2002), DFGOT vol.19 (2003), and the PATTY (4th, 1994), there is no effect on reproductive potential, only the minimum influence (growth retardation of a pup) was observed. On the other hand, based on the description that reduction of live newborns and increase of embryo absorption were observed at the dose in which dam toxicity is observed in the test which carried out inhalation exposure in the gestational age of the rat. So it was considered as Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in ACGIH (2002), DFGOT vol.19 (2003), PATTY (4th, 1994), and Society for Occupational Health Recommendation of Occupational Exposure that nasal and throat are stimulated in humans in high exposure levels, it is thought that there is respiratory irritant. And anesthetic actions is seen in humans and mice according to EHC 65 (1987), and in rats and mice inhalation exposure according to DFGOT vol.19 (2003) and PATTY (4th, 1994). Both were set as Category 3. Moreover, although central nervous system depression symptoms were seen in mice described in high inhalation exposure levels (DFGOT vol.19 (2003)) , it was judged as anesthesia action at high-concentration.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 24-hour EC50=2300mg/L of Crustacea (Daphnia magna) (EHC65, 1987).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.81*105mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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