GHS Classification Result

Chemical Name:Styrene, methyl-
CAS:25013-15-4

Result:
ID: 904
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified (with stabilizer) - - - - Classified in UNRTDG Class: 3
9 Pyrophoric liquids Not classified - - - - UNRTDG Class: 3
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - The test suitable for a liquid state substance has not been established. It is classified into the UNRTDG class 3.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was classified to category 5 based on the following lower value. Rat LD50 value: 4000mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994, NTP TR 375, 1990) and 5700mg/kg (PATTY 4th, 1994).
1 Acute toxicity (Dermal) Not classified - - - - Based on rat minimum lethal dose: 4500mg/kg (RTECS, 2005), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Based on the description that death was not observed in the rat 8 hour inhale test of 2500ppm (4 hour equivalent: 17.05mg/kg, saturated vapor) IUCLID (2000), it is presumed to be either Category 4, Category 5, or out of Category. But it cannot be decided, and thus it cannot be classified.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was set as Category 2 from description that the skin of the humans was stimulated (NTP TR 375 (1990)), and from description that irritation was admitted by the test applied to the skin of the rabbit (IUCLID (2000), RTECS (2005)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
We classified it as Category 2A-2B based on the descriptions that it stimulates the human eyes (IARC 60 (1994), and ICSC (J) (1996)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - We found only one case in IARC 60 (1994) and other data could not be found and it did not bear the criteria, therefore we presupposed that we could not classify it for the insufficiency of data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is positive result (IARC 60, 1994, NTP TR 375, 1990) by the micronucleus test which uses the mouse red corpuscles , which are the in vivo mutagenicity tests using a somatic, there is no positive result by the in vivo genotoxicity study using a germ cell. So it is set as Category 2.
6 Carcinogenicity Not classified - - - - Since it was classified into a group 3 in IARC (IARC 60, 1994) and A4 in ACGIH (7th, 2001), it was considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
From description in ACGIH (7th, 2001), PATTY (4th, 1994), and NTP TR 375 (1990) that upper respiratory irritant was seen in human exposure, and from description in NTP TR 375 (1990) that the central nervous system depressions is seen by higher level of human exposure, it was set as Category 3 (respiratory irritation, anesthesia action).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (liver, respiratory system, kidney) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, respiratory system, kidney)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
We classified it as Category 1 (nervous systems) based on the description that the effect on the central nervous system was observed in human occupational exposure examples (IARC 60 (1994)). Moreover, based on the description that the effects on the liver and on the respiratory system were observed with the concentration a little exceeding the guidance value range of Category 2 in the 15-day inhalation exposure test using the rat (NTP TR 375 (1990)), and based on the descriptions that increased development of nephropathy was observed with concentration of the guidance value range of Category 2 in the 13-week inhalation exposure test using the rat (ACGIH (7th, 2001) and NTP TR 375 (1990)), we classified it as Category 2 (liver, respiratory organs, kidney).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96-hour LC50=23.4mg/L of fishes (Fathead minnows) (IUCLID, 2000).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3, since acute toxicity was Category 3 and supposed not rapidly degrading (BIOWIN), though less bio-accumulative (BCF=35 (IUCLID, 2000)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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