GHS Classification Result

Chemical Name：Ether, bis(2-chloroethyl)-
CAS：111-44-4

Result：
ID: 900
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible (Category 3 or Category 4) Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point data available from materials are distributed in both Category 3 and 4. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: Category 3: 23 degC<= flash point <=60 degC; Category4: 60 degC< flash point <=93 degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 365degC (Hommel, 1991 Card No.473)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1, Subsidiary risks Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :75mg/kg; , 105mg/kg and 150mg/kg; REFERENCE SOURCE: PATTY 4th (1994)
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rabbit LD50 value: 870mg/kg (ATSDR, 1989).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on Rat LC50 (4 hours) value: 20 ppm (CaPSAR, 2005), it could be judged from vapor pressure as the steam with almost no mist, and classified by the ppm concentration standard as Category 1.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that irritation was admitted in the test applied to the skin of the rabbit (ATSDR (1989)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		We classified it as Category 2B based on the descriptions that moderate ocular change was acknowledged which recovers within 24 hours in the tests applied to the eyes of the rabbits (ACGIH (7th, 2001) and PATTY (4th, 1994)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Since data was insufficient, we could not classify it.
5 Germ cell mutagenicity Classification not possible - - - - There is a negative result (IARC 71, 1999, ATSDR, 1989) by joint examination with rat liver DNA which is an in vivo genotoxicity study using a somatic cell, and there is no positive finding of several indices by an in vitro mutagenicity test. So it cannot classify.
6 Carcinogenicity Not classified - - - - It was classified into B-2 (IRIS, 2005) in EPA (1994) and category 3 (EU-Annex I, 2005) in EU. But it was classified into a group 3 (IARC 71, 1999) in IARC and A4 (ACGIH 7th, 2001) in ACGIH. So it was considered as the outside of Category according to ACGIH which is latest assessment document, .
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		From description in ACGIH (7th, 2001), PATTY (4th, 1994), CaPSAR (2005), ATSDR (1989), Society for Occupational Health Recommendation of Occupational Exposure (1993), and IARC 71 (1999) that the violent irritation against respiratory tracts is seen in humans, and from description in ACGIH (7th, 2001), PATTY (4th, 1994), and ATSDR (1989) that death from lung damage was seen in the inhalation exposure test using guinea pigs. So it was set as Category 1 (respiratory tracts) . Moreover, description in Society for Occupational Health Recommendation of Occupational Exposure (1993) that an anesthetic actions is seen in high concentrations, and from description in PATTY (4th, 1994) and ATSDR (1989) that unconsciousness was seen in the inhalation exposure test using guinea pigs. So it was set as Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Based on the description that toxicity was not observed with the concentration of the guidance value range of Category 2 in the inhalation exposure test for 130 days using the rats and guinea pigs (ACGIH (7th, 2001), PATTY (4th, 1994) and ATSDR (1989)), there was a possibility that it was Out Of Category, however, it was the examination of only single exposure concentration, so relation between dosage and toxicity etc. otherwise is not clear, and there is no such description that data and hazards are very low that clearly reports hazardousness, therefore we presupposed that we could not classify since the data is insufficient.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1996).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=17200mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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