GHS Classification Result

Chemical Name：Toluene, 4-tert-butyl-
CAS：98-51-1

Result：
ID: 895
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible (Category 3 or Category 4) Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Available flash point data are distributed in both Category 3 and 4. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: Category 3: 23 degC<= flash point <=60 degC; Category4: 60 degC< flash point <=93 degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 510degC (Hommel, 1991 Card No.453)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value: 1500mg/kg (ACGIH 7th, 2001) and 1.8 mL/kg (reduced values of 1550mg/kg) (PATTY 4th, 1994). Based on the data above, it was classified to category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50 value: 19.6mL/kg (reduced value = 16880mg/kg) (PATTY 4th, 1994), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on Rat LC50 (4 hours) value: 248ppm (equivalent: 1.5 mg/L) (ACGIH 7th, 2001, PATTY 4th, 1994), it could be judged from vapor pressure as the steam with almost no mist. And it was classified by the ppm concentration standard as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Category 4 because of "SPECIES: Rat; ENDPOINT: LC50(1hr.); VALUE: 934ppm(4hr).; VALUE:1.41mg/L"(ACGIH 7th, 2001)
2 Skin corrosion/irritation Classification not possible - - - - Since change which corresponded to basis of irritation in the skin irritation test using the rabbit indicated was not admitted (RTECS (2005) and IUCLID (2000)), there was possibility besides Category. But there was no data which negated hazard clearly in Priority1, it was presupposed that it could not be classified.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		We classified it as Category 2A-2B based on the description that the moderate irritant property on the conjunctiva was acknowledged in the test applied to the eyes (ACGIH (7th, 2001)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was description that sensitizing property was not acknowledged in Maximization test which used the guinea pigs in IUCLID (2000), we presupposed that we could not classify it since there were no data which negates hazardousness clearly in Priority 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1B based on the description that the influence of the pathology histology inspection results of sperm analysis results, a testis, and an epididymis and the low value of the conception rate were observed in the reproduction toxicity studies using the rat (the Health, Labor and Welfare Ministry reports (2005)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in ACGIH (7th, 2001) that stimulation of nasal mucosa and dizziness were seen in human exposure, it was judged that it had respiratory irritant and anesthetic actions, and it was set as Category 3 (respiratory irritant, anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, blood, liver, heart), Category 2 (testis) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, blood, liver, heart)
H373: May cause damage to organs through prolonged or repeated exposure (testis) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that giddiness, headache, tremor, arrhythmia, anemia, jaundice was observed in human occupational exposure, and based on the description that the inhalation exposure test using the rats, influence on liver, blood, and nervous system was acknowledged in the guidance value range of Category 1 (ACGIH (7th, 2001)), it was classified to be Category 1 (nervous system, blood, liver, heart). Moreover, since the effect on the testes was observed with the dose in the guidance value range of Category 2 in the oral administration test for 28 days using the rat (the Health, Labor and Welfare Ministry Reports (2005)), we classified it to be Category 2 (testicular).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=1.5mg/L of Crustacea(Daphnia magna) (MOE eco-toxicity tests of chemicals, 1999).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 52% (existing chemical safety inspections data)), though less bio-accumulative (BCF=1.2 of the pivalic acid which was a change product (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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