GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Oxirane, (butoxymethyl)-
CAS：2426-08-6
Result：
| ID: | 891 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Classification not possible (Category 3 or Category 4) |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point data are distributed in Category 3 and 4. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: Category 3: 23 degC<= flash point <=60 degC; Category4: 60 degC< flash point <=93 degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :2260mg/kg (ACGIH 7th, 2001; DFGOT vol.4, 1992; PATTY 4th, 1994), 2050mg/kg (DFGOT vol.4, 1992) and 2500mg/kg (DFGOT vol.4, 1992) |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on rabbit LD50 value: 788mg/kg (PATTY (4th, 1994)) and 2520mg/kg (DFGOT vol.4, 1992), the lowest values was adopted and set as Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Rat LC50 (4 hours) value: 2590ppm (13.77mg/L) could be judged from vapor pressure as the steam with almost no mist, and classified by the ppm concentration standard as Category 4. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was set as Category 2 from description that the skin was stimulated as effect of the humans (ACGIH (7th, 2001), DFGOT (vol.4, 1992), PATTY (4th, 1994)). |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
We classified it as Category 2A-2B based on the descriptions that irritation was acknowledged by the test applied to the eyes of the rabbits (DFGOT (vol.4, 1992) and PATTY (4th, 1994)). Since the degree of irritation was different by the tests, we could not classify it deliberately. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
There was description that sensitizing property was recognized in two skin sensitivity tests for the human in DFGOT (vol.4, 1992), moreover, there were descriptions that skin sensitizing property was reported in human by ACGIH (7th, 2001) and PATTY (4th, 1994), therefore, we classified it as Category 1. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no clear positive finding with in vivo mutagenicity test using germ cells, and there is a positive result with micronucleus test on mice, which is an in vivo mutagenicity test using somatic cells (DFGOT vol.4, 1992 and PATTY 4th, 1994). Since there was no data of in vivo genotoxicity study using germ cells, it was classified as Category 2 . |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since it was classified into the category 3 of carcinogenesis in EU, it was considered as Category 2 according to table 1 of an indicator. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 (respiratory irritant) from description in DFGOT (vol.4, 1992) that respiratory irritant was seen in evidence of human exposure. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the description that in the 28-day inhalation exposure test using the rat, nasal mucosa degeneration and respiratory epitheliums dysplasia (metaplasia) were observed with the exposures in the Category 1 guidance value range (DFGOT (vol.4, 1992) and PATTY (4th, 1994)), it was classified into Category 1 (respiratory systems). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |