GHS Classification Result

Chemical Name：Propane, 1-nitro-
CAS：108-03-2

Result：
ID: 884
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 3
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC, UNRTDG Class: 3, PGIII
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 3
9 Pyrophoric liquids Not classified - - - - Flash point: 420degC (Hommel, 1991 Card No.298)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 3
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 455 mg/kg REFERENCE SOURCE: RTECS (2005), HSDB (2005) SPECIES: Rat ENDPOINT: LD50 VALUE: 484 mg/kg REFERENCE SOURCE: IUCLID (2000)
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbits lethal dose: >2000mg/kg (RTECS, 2005) and rabbit LD50 value: >2000mg/kg (IUCLID, 2000), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (1 hour) value: 11.02 mg/L (4 hour equivalent: 5.51mg/L, 1514ppm), it was classified . Since 5.51 mg/L was judged to be steam with almost no mist from vapor pressure, it was classified according to the ppm concentration standard. it was classified as Category 3.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - IUCLID (2000) had description that skin irritation was not admitted by the test which used the rabbit. But there was description that the skin might be stimulated (HSFS (2002), SITTIG (4th, 2002)). So it could not be classified since data was insufficient.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is the description that in humans eye irritations were acknowledged by exposure to vapor (ACGIH (7th, 2001), PATTY (4th, 1994), and DFGOT (vol.13, 1999)), and the description that the eyes are stimulated seriously (ICSC (J) and (1996)). So it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was description that skin sensitization was not acknowledged in IUCLID (2000) with the guinea pigs, we had no description which clearly negates sensitizing property in Proprity 1, therefore we presupposed that we could not classify it.
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result with the micronucleus test on rat and mouse red corpuscles which is an in vivo mutagenicity test using somatic cells (PATTY 4th, 1994), it was classified as out of Category.
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the symptom, which is considered to be respiratory irritant and anesthetic actions, was seen in the inhalation exposure test using the rabbits as described in ACGIH (7th, 2001), it was set as Category 3 (respiratory irritant, anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Based on the description that in the 21.5-months inhalation exposure test using the rat, the toxicity which endorses the classification of the concentration exceeding the Category 2 guidance value range is not observed (ACGIH (7th, 2001) and PATTY (4th, 1994)), and in the 28-days oral study (good laboratory practice tests) using the rat, the toxicity is not acknowledged with the dosage in the the Category 2 guidance value range (IUCLID (2000)), it was classified into the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour ErC50=20mg/L of algae (Selenastrum) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD of 2-nitro propane: 8% (existing chemical safety inspections data)), though less bio-accumulative (log Kow=0.87(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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