GHS Classification Result

Chemical Name:Toluene, 3-nitro-
CAS:99-08-1

Result:
ID: 881
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 6.1
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC, UNRTDG Class: 6.1
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 6.1
9 Pyrophoric liquids Not classified - - - - Flash point: 440degC (Hommel, 1991 Card No.361a)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 6.1
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Rat LD50 value: 1072mg/kg, 2000mg/kg and 2200mg/kg (IARC 65, 1996). Since the calculated value was 1187mg/kg, it was classified to category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Rabbit LD50 value : >20000mg/kg (HSDB, 2005), rat LD50 value: >1157mg/kg (IUCLID, 2000, BUA 41, 1989). So category could not be specified, it cannot be classified due to insufficient data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is only a data with rat LC50 (4 hours) value: >157ppm (equivalent 0.879mg/L) in HSDB (2005), Category cannot be specified due to data insufficiency.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The category cannot be specified by only data that rat LC50 (1 hour) value: >2.417mg/L (4-hour equivalent 0.6043mg/L) ( IUCLID (2000), BUA 41 (1989)). And data is insufficient, it cannot be classified.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that the skin was stimulated slightly (ICSC (J) (2000), HSDB (2005).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description that the skin is stimulated slightly (ICSC (J), (2000), and HSDB (2005)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result with micronucleus test on rat and mouse red corpuscles which is an in vivo mutagenicity test using somatic cells (NTP DB, 2005), it was classified as out of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into the group 3 (IARC 65, 1996) in IARC, it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 2 based on the description that testicular dysfunction, such as low sperm count etc., and the female abnormalities of estrous cycle were observed at the dose causing general toxicity, such as a low value of weight etc., in the feeding oral administration tests using the rat and mouse (ACGIH (7th, 2001) and IARC 65 (1996)) .
8 Specific target organ toxicity - Single exposure Category 2 (blood) Warning H371: May cause damage to organs (blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 (blood) from description in ICSC (J) (2000) that blood may be affected and methemoglobin may be produced.
9 Specific target organ toxicity - Repeated exposure Category 2 (immune system) Warning H373: May cause damage to organs through prolonged or repeated exposure (immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description that in the oral study using the mouse, the effects on the immune systems were observed with the dosage in the Category 2 guidance value range (NTP DB (2005) and PATTY (4th, 1994)), it was classified into Category 2 (immune systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48-hour EC50=7400microg/L of Crustacea (Daphnia magna), and others (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 2% (existing chemical safety inspections data)), though less bio-accumulative (BCF=12 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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