GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：nitrogen dioxide
CAS：10102-44-0
Result：
| ID: | 874 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Non-combustible (ICSC(J), 1997) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Category 1 |
|
Danger | H270: May cause or intensify fire; oxidizer |
P370+P376: In case of fire: Stop leak if safe to do so. P220: Keep/Store away from clothing/.../combustible materials. P244: Keep reduction valves free from grease and oil. P403: Store in a well-ventilated place. |
UNRTDG Class: 2.3, Subsidiary risks Class: 5.1 |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temp: >-50degC (Partially liquid at temperatures above -50degC) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Although there is information that it corrodes steel at the time of wetting (HSDB (Access on Sep. 2005)), test methods suitable for gaseous substances are not established. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Dermal） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Gases） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 1 based on rat LC50 (4 hours) value: 88ppm (RTECS, 2005, HSDB, 2005) and rat LC50 (1 hour) value: 0.22mg/L (4-hour equivalent of 58ppm) (RTECS, 2005). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was set as Category 2 from description that the skin was stimulated (ICSC (J) (1997), HSFS (2000)) . |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the description that the eyes are stimulated seriously (ICSC (J), (1997), and HSFS (2000)), it was set as Category 2A-2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | There are negative result with the chromosome aberration test on mouse spermatogenous cell using germ cells which is an in vivo mutagenicity test (EHC 188, 1997), negative result with chromosome aberration test on mouse peripheral lymphocyte which is an in vivo mutagenicity test using somatic cells and the micronucleus test on mouse red corpuscles (EHC 188, 1997). So it was classified as out of Category. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Not classified because of "A4" (ACGIH, 7th, 2001) |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into Category 2 based on the description that specific reproductive toxicity (increase in postimplantation death) was observed at the dose causing general toxicity to maternal animals in an pregnant rat inhalation exposure test (EHC 188 (1997)). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (lung) |
|
Danger | H370: Causes damage to organs (lung) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
From description in ACGIH (7th, 2001), PATTY (4th, 1994), and EHC 188 (1997) that the influence on lung function and accumulation of pulmonary edemas were seen in evidence of human exposure, it was set as Category 1 (pneumoconiosis) . |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (lung, immune system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (lung, immune system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the description that prolonged exposures cause lung diseases in the human (ACGIH (7th, 2001), EHC 188 (1997), and PATTY (4th, 1994)), the description that resistance to infections declines in the human (EHC 188 (1997) and PATTY (4th, 1994)), and the description that in the laboratory animals by repeated inhalation exposures, the effects on the lung and immunity declines were observed with the concentration in the Category 1 guidance value range (ACGIH (7th, 2001), EHC 188 (1997), and PATTY (4th, 1994)), it was classified into Category 1(lung, immune systems). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96-hour LC50=38520microg/L of Crustacea (Redtail prawn) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Toxicity factor is considered to be strong acid as aqueous solution, but toxic effect is eased by the buffer action in the environmental water. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |