NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Disodium disulphite
CAS：7681-57-4

Result：


ID:	871
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Air oxidations Speeds is very slow.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	The aqueous solution is stable.
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified	-	-	-	-	Reducing substance
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic substance
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Category 4 based on SPECIES: Rat; ENDPOINT: LD50; 1310mg/kg; (Ave. value)
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid
1	Acute toxicity （Inhalation: Vapours）	Not applicable	-	-	-	-	Nonvolatile solid
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Although an animal experiment shows unstimulation, there is also information that an irritation is given to humans with concentrated solution.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since there is a Mild stimulate and has been recovered in three days (ECETOC Report), it was set as "Category 2B".
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	In the human epidemiological information, although in a few cases, allergy by the inhalation, skin contacts and oral intakes is reported. It is said that it happens to the human with sulfite oxidase deficiency. The incidence rate is not high. (Specialist opinion confirmed)
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	In the human epidemiological information, although in a few cases, allergy by the inhalation, skin contacts and oral intakes is reported. It is said that it happens to the human with sulfite oxidase deficiency. The incidence rate is not high. (Specialist opinion confirmed)
5	Germ cell mutagenicity	Not classified	-	-	-	-	The result of in vivo tests was negative with mutagenicity test on mice and generation of mice. Although the positive result was found with in vitro examination, it was classified as "out of Category." by the guideline. [The basis sentence was corrected according to expert's opinion]
6	Carcinogenicity	Not classified	-	-	-	-	Since it was considered as a class 3 in IARC and A4 in ACGIH, it was considered as "out of Category ".
7	Reproductive toxicity	Not classified	-	-	-	-	It was considered as out of Category since the adverse effect was not reported in examination of many generations.
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Since there was information that shows respiratory stimulus in human exposure to aerosol, it wasset as "Category 3 (respiratory irritation)."
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since there is a report of asthema in laundry workers and food ingestion person (ACGIH (2001), it was classified into Category 1 (respiratory tracts). (It was amended by expert's opinion)
10	Aspiration hazard	Classification not possible	-	-	-	-	Insufficient data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 48-hour EC50=88.76mg/L of Crustacea (Daphnia magna) (SIDS, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3, since acute toxicity was Category 3, and behavior in water is unknown, though supposed less bioaccumulative.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）