GHS Classification Result

Chemical Name：Naphthalene
CAS：91-20-3

Result：
ID: 869
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Category 2 Warning H228: Flammable solids P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		UNRTDG Class: 4.1; PG III
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 526degC (NFPA, 12th, 1997, p49-93)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Rat LD50 value : Caluculation was applied based on the following data: About 1800mg/kg (ACGIH 7th, 2001), 1780mg /kg (DFGOT vol.11, 1998), 9430mg /kg (DFGOT vol.11, 1998, CERI Hazard Data, 1997, NTP TR500, and 2000), 1110mg/kg (DFGOT vol.11, 1998, EHC 202, 1998, NTP TR500, 2000), 2200mg/kg(DFGOT vol.11, 1998, EHC 202, 1998, ATSDR, 2003), > 2000mg /kg (EU RAR, 2003),, 2300mg/kg (EU RAR, 2003), 490mg/kg (CERI Hazard Data, 1997, EHC 202, 1998), 1250mg/kg (EHC 202, 1998), 1800mg/kg (EHC 202, 1998), and 2600mg/kg (ATSDR, 2003). Since the calculated values was 1157mg/kg, this value was classified to category 4.
1 Acute toxicity （Dermal） Not classified - - - - From rat LD50 value: >2500mg/kg (CERI Hazard Data, 1997, EHC 202, 1998, NTP TR500, 2000), rabbit LD50 value: >2000mg/kg (EU RAR, 2003, and CERI Hazard Data, 1997), and the description that death was not observed in a rat at 2500mg/kg (EU RAR (2003)), and description that death was not observed in a rabbit at 2000mg/kg (ATSDR (2003)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Since there are only descriptions that rat LC50 (1 hour) value: >65ppm (4-hour equivalent: 0.17mg/L) (CERI Hazard Data (1997)) and rat LC50 (8 hours) value: >0.5mg/L (4-hour equivalent: >0.7mg/L) (NTP TR500 (2000)), data was insufficient for specifying Category. And it was presupposed that it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that mild irritation was admitted in the test applied to the rabbit skin (DFGOT (vol.11, 1998), EU RAR (2003), EHC 202 (1998), ATSDR (2003)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is the description that in the test applied to the eye of the rabbit, the mild irritation recovered within seven days was acknowledged (EU RAR (2003) and ATSDR (2003)). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		We have the description that skin sensitizing property was not acknowledged in Buehler test and maximization test which used the guinea pigs in EU RAR (2003), however, based on the description of 2 cases in which the cutireaction was acknowledged by the intracutaneous test of DFGOT (vol.11, 1998) as influence to human and on the description that the frequency of allergic reactions against the naphthalenes is 0.13%, we classified it to be Category 1.
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result with the micronucleus test on mouse erythrocyte which is an in vivo mutagenicity test using somatic cells (DFGOT vol. 11, 1998, EU RAR2003 and IARC82, 2002, IRIS1998, ATSDR2003), it was classified as out of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into A4 (ACGIH 7th, 2001) in ACGIH and CBD (IRIS, 2005) in EPA (1998). But it was classified into group 2B (IARC 82, 2002) in IARC, and the category 3 (EU-Annex I, 2005) in EU. So it was considered as Category 2 according to IARC which is latest assessment document.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that specific reproductive toxicity was not observed at the dose causing toxicity to maternal animals in a pregnant rat, mouse and rabbit oral administration examination (NTP DB (2005), DFGOT (vol.11, 1998), EU RAR (2003), IARC 82 (2002), EHC 202 (1998), IRIS (1998), ATSDR (2003), and ACGIH (7th, 2001)).
8 Specific target organ toxicity - Single exposure Category 1 (blood), Category 2 (eye) Danger
Warning 		H370: Causes damage to organs (blood)
H371: May cause damage to organs (eye) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		From description in ACGIH (7th, 2001), DFGOT (vol.11, 1998), EU RAR (2003), IARC 82 (2002), EHC 202 (1998), IRIS (1998), CERI Hazard Data (1997), NTP TR500 (2000), ATSDR (2003), and ACGIH (7th, 2001) that hemolytic anemia was seen in humans, it was set as Category 1 (blood). Moreover, from description ACGIH (7th, 2001), DFGOT (vol.11, 1998) and EHC 202 (1998) that cataract development was seen by the dosage of the guidance value range of Category 2 in the single-dose oral study which used the rabbits, it was set as Category 2 (eye).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, eye, nose) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, eye, nose) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that hemolytic anemias was acknowledged by repeated inhalation of low concentrations exposure in humans (DFGOT (vol.11, 1998)), the description that in the occupational evidence of exposure , lens opacity was observed (ACGIH (7th, 2001), DFGOT (vol.11, 1998), EU RAR (2003), IRIS (1998), CERI Hazard Data (1997), NTP TR500 (2000) and ATSDR (2003)), and the description that in the inhalation exposure test using the rat, the change of olfactory epithelium was observed with the Category 1 guidance value range (EU RAR (2003)), it was classified into Category 1 (blood, eyes, nasal ).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.11mg/L of fishes (Rainbow trout) (CERI Hazard Data, 1997).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=168 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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