GHS Classification Result

Chemical Name：Benzene, trimethyl-
CAS：25551-13-7

Result：
ID: 868
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >=23degC and <=60degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 450-550degC (ICSC (J), 2002)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 8970 mg/kg REFERENCE SOURCE: RTECS (2005), HSDB (2005)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since it had descriptions that there were primary skin irritation (animal species were unknown) (ACGIH (7th, 2001)), moderate irritation to a rabbit (RTECS (2005)). And also skin irritation as human impact without the concrete case report were shown ( HSDB (2005), HSFS (2003), and SITTIG (4th 2002)). So it was set as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is description that there is mild irritation to a rabbit (RTECS (2005)), the description that although the concrete case report etc. are not shown, as human effects, redness and pains in the eyes are started (ICSC (J) (2002)), and the description that there are eye irritations also (HSFS (2003), SITTIG (4th 2002)). So it was rset as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		ACGIH (7th, 2001) has description showing "it was thought that the potential of the systemic poisoning by transdermal absorption was low." As impact on humans, there are descriptions in ICSC (J) (2002) that inhalation exposure or oral ingestion cause distraction, cough, giddiness, drowsy, headache, pharyngeal pain, vomiting, and respiratory tract stimulus, and description that the central nervous systems might be affected. HSDB (2005) has description "it is mildly toxic by ingestion," and HSFS (2003) and SITTIG (4th 2002) have description "giddiness and the head unsteady, and consciousness may be lost by inhalation exposure." Furthermore, SITTIG (4th 2002) has description "an airway is stimulated by inhalation exposure and may show the similar symptoms as described in ICSC (J) and (2002) " as well. Based on the above, it was judged that there were respiratory irritant and an anesthetic actions, and all were set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 2 (skin, respiratory system, blood, central nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (skin, respiratory system, blood, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that cracks because of defatting of the skin are caused by repeated skin exposures to the humans (ICSC (J), (2002), SITTIG (4th, 2002)), and the description that by the repeated inhalation exposures (ICSC (J), (2002), SITTIG (4th, 2002), HSFS (2003), there are lung irritation or chronic bronchitis, coagulation effects, and the effects on the central nerves system such as headaches and nervousness etc., it was classified into Category 2 all, since skin, respiratory systems, blood, and central nervous systems were considerd to be target organs
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Trimethyl benzene is a hydrocarbon. There is a descriptionthat among the three isomers, the viscosity of 1, 2, 4-trimethyl benzene and 1, 3, 5-trimethyl benzene are 0.730mPas (30 degrees C) and 1.154mPas (20 degrees C), respectively (Lange (14th, 1992)). Based on these each viscosity data and on the fact that the densities of these 3 isomers are smaller than 0.9, it is judged that the dynamic viscosity of trimethyl benzene at 40 degrees C (the mixture of three isomers) is fully less than 20.5mm 2/s. Moreover, there is a description that [there is a risk of chemical pneumonia by aspiration if the fluid is swallowed](ICSC (J) (2002)), and 1, 2, 3-trimethyl benzene and 1, 3, 5-trimethyl benzene are explained. Furthermore, there is the description that [bronchitis or chemical pneumonia will be caused if the liquid enters into the lungs](SITTIG (4th, 2002)), and we classified it as Category 1 based on these descriptions.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=5400microg/L of Crustacea (glass shrimp) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (by analogy with the decomposition by BOD of 1, 3, 5-trimethylbenzene: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=328 of 1, 3, 5-trimethylbenzene (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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