GHS Classification Result

Chemical Name：Trimethylamine
CAS：75-50-3

Result：
ID: 867
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Ignitable when in a mixture of 13% or less by volume in air. UNRTDG Class: 2.1
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - UNRTDG Class: 2.1
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temp: >-50degC (Partially liquid at temperatures above -50degC)
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		In the reference of Priority 1, there are two rat LD50 values: 396.9mg/kg (the Health, Labor and Welfare Ministry reports, 2005) and 500mg/kg (ACGIH, 2001). The lower value (former) was applied to categorize, and it was set as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 value ( >5000mg/kg) (IUCLID, 2000), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It is classified into Category 4 based on the lower value (LC50 = 3519ppm) among two rat LC50 = 3519ppm (IUCLID, 2000) and 4264ppm (IUCLID, 2000)(in the source of Priority 2).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 1A Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is mentioned that corrosive to human skin (ACGIH (7th.2001), CERI Hazard Data (1997)). From description that after making human skin contact several minutes, even if washing with soap and water, petechiation was seen, softening of the skin continued for 1 - 2 hours, and desquamation was observed 2 - 3 hours later (ACGIH, 2001), it was set as Category 1A.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is the description about the humans and the animal (ACGIH and 2001), i.e., that erosion of the corneal epithelium by eyes exposure in humans by the accident, and that in the eye tests to the eyes of the animals, conjunctival bleed and corneal edema and turbidity were obsedved. But the either case was transitory change and recovered within seven days, it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - There are no in vivo mutagenicity or genotoxicity study data using germ or somatic cells, and it is weak positive in the in vitro chromosomal aberration test using a Chinese hamster lung origin cell (the Health, Labor and Welfare Ministry reports, 2005). But it was negative in the reverse mutation test using bacterial cells (the Health, Labor and Welfare Ministry reports, 2005, ACGIH, 7th, 2001, NTP DB, 2005, IUCLID, 2000, CERI Hazard Data, 1997). Therefore, it was presupposed that it cannot be classified.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - It was considered as out of Category since it is not observed in any parameter about reproductive developmental toxicity ad dose of 200 mg/kg/day causing little lethality to parent animals in rat repeated oral toxicity/ preroductive developmental toxicity annexation test (the Health, Labor and Welfare Ministry reports, 2005).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in ACGIH (7th, 2001) that RD50 (concentration which a mean respiratory rates reduces by half) of sensory stimulation was 61ppm in inhalation exposure to mice, it was judged that there was respiratory irritant, and was set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in the two-week inhalation exposure test to the rat, the respiratory mucosal degeneration was observed with the dosage in the Category 2 guidance value range (ACGIH (7th.2001), CERI Hazard Data (1997)), it was classified into Category 2, as the target organs were considerd to be respiratory tracts.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour EC50=74.2mg/L of algae (Scenedesmus) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 92% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.16 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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