GHS Classification Result

Chemical Name：ferbam
CAS：14484-64-1

Result：
ID: 864
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (1997))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Although there is the information that water is contacted and inflammable gas is produced (ICSC (J) (1997)), no data based on a set test method.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Considering the description of "Rat LD50 value=>4000mg/kg (EHC 78 (1988))", and that 1 rat among 10 rats died from the 17000mg/kg medication (ACGIH (7th, 2001) and DFGOT (vol.18, 2002)), the value was regarded out of category.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of "SPECIES: Rat; ENDPOINT: LC50(4hr.); VALUE: 0.4mg/L"(HSDB, 2006)
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From description that dermatitis is caused to part humans (ACGIH (7th, 2001), DFGOT (vol.18, 2002)), it was judged that there was skin irritation and, it was set as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description that in the test applied to the eye of the rabbit, mild irritation was acknowledged (HSDB (2006)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - It is judged as negative based on the description in HSDB (2006) that positive rates were 5% in the skin sensitivity test which used the guinea pigs, however, there was description that sensitization of the skin may be expressed as influence to the human (though no case reports were made) in HSDB (2006), ICSC (J), (1997), HSFS (1999), and SITTIG (4th, 2002), therefore we presupposed that we could not classify it because of the insufficiency of the data .
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it is classified into a group 3 (7 IARC Suppl. 1987) in IARC and A4 (ACGIH 7th, 2001) in ACGIH, it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 2 based on the description that it is observed malformation of offspring at dose causing general toxicity to maternal animal in pregnant rat oral administration test (EHC 78 (1988) and the DFGOT (vol.18, 2002)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description in ACGIH (7th, 2001) and DFGOT (vol.18, 2002) that respiratory irritant is seen in humans, and description in HSDB (2006) that central nervous system depressions was seen in the single oral administrations to rats, it was thought that there were respiratory irritant and an anesthesia action. So it was set as Category 3 (respiratory irritant, anesthesia action).
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid, nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (thyroid, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that the effects on the nervous systems were observed with the dosage a little exceeded the Category 2 guidance value range in the two-years oral study using the rat, and with the dosage in the Category 2 guidance value range in the oral study for one year using the dog (EHC 78 (1988)), and the description that in the 80-weeks feeding oral administration tests using the rat, the effects on the thyroid and nervous systems were observed with the dosage in the Category 2 guidance value range (DFGOT (vol.18, 2002)), it was classified into Category 2 (thyroid, nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=0.09mg/L of Crustacea (Daphnia magna), and others (EHC78, 1988).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=-1.6(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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